The influence of tau and inflammation on hippocampal neuron function

在过去，阿尔茨海默病的研究主要集中在淀粉样蛋白病理学上，使用APP转基因小鼠等模型来模拟这种疾病，不幸的是，由于淀粉样蛋白假说存在缺陷，这种研究未能开发出任何成功的药物治疗方法。最近的文献表明，AD病理进展的主要因素可能是Tau蛋白的过度磷酸化，而不是ab。似乎Tau蛋白的存在是APP Tg小鼠认知功能受损的先决条件，这表明Tau蛋白在神经元信号传导受损中起主导作用。此外，我热衷于研究其他非神经元细胞类型在阿尔茨海默病病理中的作用。在本科期间，我对中枢神经系统中非神经元细胞在维持组织稳态和维持健康细胞信号传导方面的重要性有了一定的认识。胶质损伤对切片培养的影响值得关注

In the past AD research has focused on amyloid pathology, usingmodels such as APP transgenic mice to model the disease, which unfortunately has failed to result in the development ofany successful pharmacological treatments, likely due to the amyloid hypothesis being flawed. More recent literatureindicates the main factor underlying the progression of AD pathology may be Tau hyper-phosphorylation rather than AB.It seems that the presence of Tau protein is a prerequisite for impairment of cognition in APP Tg mice, suggesting apredominant role for Tau in impaired neuronal signalling. Also, I am keen to investigate the role that other non-neuronalcell types might have in AD pathology. During my undergraduate degree I have gained an appreciation for theimportance of non-neuronal cells in the CNS for maintaining tissue homeostasis and potentially for maintaining healthycell signalling. The effect of glial impairment in slice culture could be of interest