Prospective Memory in Everyday Life: Lapses and Decline in Relation to Inflammatory and Neurodegenerative Biomarkers in Older Adults

日常生活中的预期记忆：与老年人炎症和神经退行性生物标志物相关的衰退和下降

• 批准号: 10644046
• 负责人: Erin Harrington
• 金额: $ 1.34万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10644046
• 关键词: Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Amyloid beta-42; Amyloid beta-Protein; Appointment; Behavioral; Biological; Biological Markers; Blood; Caregivers; Child; Cognition; Cognitive; Data; Data Analyses; Dementia; Disease Progression; Early Diagnosis; Early identification; Ecological momentary assessment; Elderly; Frequencies; Future; Gender; Goals; Healthcare Systems; Immune; Impaired cognition; Individual; Inflammation; Inflammatory; Inflammatory Response; Intervention; Investigation; Late Onset Alzheimer Disease; Life; Link; Measurement; Measures; Memory; Memory Loss; Memory impairment; Nerve Degeneration; Parents; Participant; Pathologic; Pathology; Patient Self-Report; Patients; Pharmaceutical Preparations; Predisposition; Procedures; Protocols documentation; Research; Research Personnel; Risk; Running; Sampling; Sex Differences; Surveys; Technology; Time; Woman; Work; aged; base; cognitive ability; cognitive change; dementia risk; effective therapy; experience; forgetting; gender difference; human old age (65+); improved; inflammatory marker; innovation; insight; member; men; mild cognitive impairment; neglect; novel; programs; prospective memory; protective factors; psychosocial; resilience; sex; social expectations; tau-1

PROJECT SUMMARY Prospective memory (PM) refers to memory for future intentions, such as attending an appointment or taking medication. Research suggests that, compared to other cognitive measures, PM deficits can better distinguish healthy older adults from those with mild cognitive impairment or in early stages of dementia. However, limited work has examined PM and biological correlates of pathological memory decline, such as inflammatory and neurodegenerative biomarkers. The proposed project will use unanalyzed data existing within the Einstein Aging Study (EAS) to examine older adults’ everyday PM lapses in association with markers of inflammation (Aim 1) and neurodegeneration (Aim 2) at cross-section and longitudinally. Analyses will also address the moderating effect of gender/sex in the proposed links between PM, inflammation, and neurodegeneration (Aim 3). Findings from the proposed project will advance our understanding of the biological underpinnings of PM. Additionally, findings will provide valuable insight into biological conditions related to inflammation and neurodegeneration that may explain when PM declines are indicative of cognitive impairment, as well as whether the hypothesized relationships differ by gender/sex.

项目摘要 前瞻性记忆（PM）是指对未来意图的记忆，例如参加约会或参加 药研究表明，与其他认知指标相比，PM缺陷可以更好地区分 健康的老年人与轻度认知障碍或早期痴呆症患者的区别。但受限 研究人员已经研究了PM和病理性记忆衰退的生物学相关性，如炎症和 神经退行性生物标志物。拟议中的项目将使用爱因斯坦望远镜中现有的未经分析的数据。 老化研究（EAS）检查老年人的日常PM失误与炎症标志物的关系 (Aim 1）和神经变性（目的2）在横截面和纵向。分析还将涉及 性别/性别在PM、炎症和神经变性之间的联系中的调节作用（目的 3）。该项目的发现将促进我们对PM生物学基础的理解。 此外，研究结果将为与炎症相关的生物学状况提供有价值的见解， 神经退行性变，可以解释当PM下降时是认知障碍的指示，以及 假设的关系是否因性别而异。