Prospective Memory in Everyday Life: Lapses and Decline in Relation to Inflammatory and Neurodegenerative Biomarkers in Older Adults

日常生活中的预期记忆：与老年人炎症和神经退行性生物标志物相关的衰退和下降

• 批准号: 10644046
• 负责人: Erin Harrington
• 金额: $ 1.34万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10644046
• 关键词: Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Amyloid beta-42; Amyloid beta-Protein; Appointment; Behavioral; Biological; Biological Markers; Blood; Caregivers; Child; Cognition; Cognitive; Data; Data Analyses; Dementia; Disease Progression; Early Diagnosis; Early identification; Ecological momentary assessment; Elderly; Frequencies; Future; Gender; Goals; Healthcare Systems; Immune; Impaired cognition; Individual; Inflammation; Inflammatory; Inflammatory Response; Intervention; Investigation; Late Onset Alzheimer Disease; Life; Link; Measurement; Measures; Memory; Memory Loss; Memory impairment; Nerve Degeneration; Parents; Participant; Pathologic; Pathology; Patient Self-Report; Patients; Pharmaceutical Preparations; Predisposition; Procedures; Protocols documentation; Research; Research Personnel; Risk; Running; Sampling; Sex Differences; Surveys; Technology; Time; Woman; Work; aged; base; cognitive ability; cognitive change; dementia risk; effective therapy; experience; forgetting; gender difference; human old age (65+); improved; inflammatory marker; innovation; insight; member; men; mild cognitive impairment; neglect; novel; programs; prospective memory; protective factors; psychosocial; resilience; sex; social expectations; tau-1

PROJECT SUMMARY Prospective memory (PM) refers to memory for future intentions, such as attending an appointment or taking medication. Research suggests that, compared to other cognitive measures, PM deficits can better distinguish healthy older adults from those with mild cognitive impairment or in early stages of dementia. However, limited work has examined PM and biological correlates of pathological memory decline, such as inflammatory and neurodegenerative biomarkers. The proposed project will use unanalyzed data existing within the Einstein Aging Study (EAS) to examine older adults’ everyday PM lapses in association with markers of inflammation (Aim 1) and neurodegeneration (Aim 2) at cross-section and longitudinally. Analyses will also address the moderating effect of gender/sex in the proposed links between PM, inflammation, and neurodegeneration (Aim 3). Findings from the proposed project will advance our understanding of the biological underpinnings of PM. Additionally, findings will provide valuable insight into biological conditions related to inflammation and neurodegeneration that may explain when PM declines are indicative of cognitive impairment, as well as whether the hypothesized relationships differ by gender/sex.

项目摘要 预期记忆（PM）是指未来意图的记忆，例如参加约会或参加 药物。研究表明，与其他认知措施相比，PM定义可以更好地区分 来自患有轻度认知障碍或痴呆症早期的健康老年人。但是，有限 工作检查了PM和病理记忆下降的生物学相关性，例如炎症和 神经退行性生物标志物。拟议的项目将使用爱因斯坦中存在的单分析数据 老化研究（EAS）检查老年人每天PM与炎症标记有关 （AIM 1）和神经变性（AIM 2）在横截面和纵向上。分析也将解决 在PM，感染和神经变性之间提出的联系中性别/性别的调节作用（AIM 3）。拟议项目的发现将提高我们对PM生物基础的理解。 此外，发现将为与炎症和 神经变性可能解释何时pm降低表明认知障碍，以及 假设的关系是否因性别/性别而有所不同。