Echocardiographic assessment of acute and chronic effects of exercise on cardiac function - from physiology to clinical practice

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This project will combine medical statistics and clinical trial design, exercise physiology and medicine in one integrated study. We propose to construct and analyse dynamic, multi-organ mathematical models to provide a means to elucidate the quantitative relationships between physiological systems and processes for paediatric patients with sub-groups of palliated congenital heart disease (biventricular repair groups).After a child has undergone corrective heart surgery, cardiorespiratory fitness is an important factor of successful outcome, but its prescription is under-utilised. This project will use systematic reviews, cardiorespiratory and echocardiography testing and an intervention providing bespoke biomedical information for the patient and clinicians.