Postdoctoral Training in the Biology of Drug Abuse

描述：（申请人提供）： 这是一份关于博士后培训补助金竞争性续期的提案 位于密歇根大学的多学科环境中。的13 教师都是NIDA赠款（或共同Pls），并在专业知识， 药物滥用的神经生物学，特别侧重于阿片类药物领域 和精神兴奋剂建议的重点是博士的培养。 和医学博士。博士后研究员在国家的最先进的研究方法 滥用精神活性药物的潜在机制。这包括研究 遗传、发育和环境因素，导致易受 药物滥用：药物滥用的分子作用方式， 细胞、解剖和行为水平;以及 通过神经机制介导的对大脑的精神活性药物 可塑性。我们的假设是大脑的功能和结构 与慢性药物使用相关的重塑是耐受性的基础， 致敏、身体依赖和心理成瘾。 密歇根大学的药物滥用研究社区 质量，并在该领域有着悠久的历史。除了他们的个人优势， 培训师资经过长期的科学培训， 彼此之间的关系这些历史优势最近被 随着大学的一系列新举措， 密歇根州，旨在促进生命科学研究的一般， 尤其是神经科学研究。它们包括最先进的工具， 小鼠和大鼠遗传学、基因组学、蛋白质组学和信息学。所以我们 学员将受益于一个高度复杂的，但非常支持， 研究和培训环境。

DESCRIPTION: (Provided by Applicant): This is a proposal for a competing renewal of a postdoctoral training grant located in a multidisciplinary setting at the University of Michigan. The 13 faculty are all NIDA grantees (or Co-Pls) and have expertise in the neurobiology of substance abuse, with particular emphasis on the area of opioid and psychostimulant drugs. The focus of the proposal is the training of Ph.D. and M.D. postdoctoral fellows in state-of-the-art approaches for studying mechanisms underlying abuse of psychoactive drugs. This includes studying the genetic, developmental and environmental factors that lead to vulnerability to substance abuse: the mode of action of drugs of abuse at the molecular, cellular, anatomical and behavioral levels; and the long-term consequences of pschoactive drugs on the brain, as mediated through mechanisms of neural plasticity. The working assumption is that the functional and structural brain remodeling associated with chronic drug use lies at the basis of tolerance, sensitization, physical dependence, and psychological addiction to these drugs. The drug abuse research community at the University of Michigan is of high quality and has a long history in the field. Beyond their individual strengths, the training faculty members have long-term scientific and training relationships with each other. These historical strengths have recently been significantly enhanced with a number of new initiatives' at the University of Michigan, designed to facilitate life sciences research in general, and neuroscience research in particular. They include state-of-the-art tools for mouse and rat genetics, genomics, proteomics, and informatics. Thus, our trainees will profit from a highly sophisticated, yet extremely supportive, research and training environment.