CSHL Cancer Gene Discover and Cancer Biology Postdoctoral Research Training

描述（由申请人提供）：冷泉港实验室（CSHL）癌症基因发现和癌症生物学博士后研究培训计划的主要目标是培养下一代癌症生物学家进行独立研究，将癌症基因发现与功能生物学相结合，以促进新的癌症治疗，诊断和/或预防策略的发展。三年研究培训计划的特点包括：强制性和选修课的教学组成部分；结构化职业发展指导；每月研究研讨会；研究生和社区教学机会；以及在CSHL国家癌症研究所（NCI）指定的癌症中心附属实验室的研究经验。博士后学员受益于19个潜在导师实验室的小教师与学员比例，现场国际知名的科学会议和课程计划，以及新扩建的最先进的癌症研究设施。癌症研究机会跨越三个高度整合的领域，由不断增长的定量生物学项目和专门的教师和资源提供增强和支持。癌症研究领域包括；1)癌症基因发现——测序、遗传模型、染色体工程；2)肿瘤基因功能-剪接、复制、表观遗传学、核结构、肿瘤生长和转移；3)人类癌症影响-药物敏感性和耐药性，临床相关性，疾病状态和结局。CSHL正在寻求NCI的国家研究服务奖机构培训资助，第一年有5个职位，接下来的四年每年有6个职位。培训项目受益于协作和多学科的研究环境，包括学员参与的内部执行委员会，以及独立的外部咨询委员会。学员将对癌症遗传学及其对与人类恶性肿瘤相关的生物过程的影响有深入和综合的了解，并准备在完成课程后从事独立的癌症研究事业。以前的审查小组提出的问题已经过仔细考虑，并在本修订后的申请中予以解决。

DESCRIPTION (provided by applicant): The primary goal of the Cancer Gene Discovery and Cancer Biology Postdoctoral Research Training Program at Cold Spring Harbor Laboratory (CSHL) is to prepare the next generation of cancer biologists to pursue independent research that integrates cancer gene discovery with functional biology in order to facilitate the development of novel cancer therapeutic, diagnostic and/or preventive strategies. Features of the three year research training program include a combination of: mandatory and elective didactic components; structured career development guidance; monthly research seminars; graduate and community based teaching opportunities; and research experiences in laboratories affiliated with the CSHL National Cancer Institute (NCI) designated Cancer Center. Postdoctoral trainees benefit from a small faculty to trainee ratio in nineteen potential preceptor laboratories, an on-site internationally renowned Scientific Meetings and Courses program, and newly expanded state-of-the-art cancer research facilities. Cancer research opportunities span three highly integrated areas that are augmented and supported by a growing Quantitative Biology program with dedicated faculty and resources. The cancer research areas include; 1) Cancer Gene Discovery - sequencing, genetic models, chromosome engineering; 2) Cancer Gene Function - splicing, replication, epigenetics, nuclear structure, tumor growth and metastasis; and 3) Human Cancer Impact - drug sensitivity and resistance, clinical correlates, disease status and outcomes. CSHL is seeking National Research Service Award Institutional Training grant support from the NCI for 5 positions in the first year, and 6 in each of the following four years. The training program benefits from a collaborative and multidisciplinary research environment, an internal Executive Committee that includes trainee participation, and an independent External Advisory Committee. Trainees gain an in-depth and integrated understanding of cancer genetics and its impact on biological processes relevant to human malignancy, and will be prepared to pursue independent cancer research careers upon completion of the program. Points raised by the previous review panel have been carefully considered and are addressed in this revised application.