POST PROCESSING & PACKAGING OF ELECTRODES: BIOPOLYMER & CHRONIC IMPLANTS

后期处理

• 批准号: 6660155
• 负责人: Jamille F Hetke
• 金额: $ 20.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6660155
• 关键词: Mammalia; bioengineering /biomedical engineering; biomedical equipment development; biomedical resource; cardiovascular system; eye; human tissue; medical rehabilitation related tag; prosthesis; technology /technique

In addition to the classic probe application areas of cortical, deep structures, peripheral nerve and neural prostheses, there is also interest in using the probes to record from other areas including cardiac muscle and tissue slices. Cardiac muscle, as with peripheral nerve, is a challenging preparation for silicon probes in that penetration is difficult and the relative movement of the structure is very large. Dr. Cascio, in collaboration with Dr. Nagle, has been successful in recording longitudinal activation in an ischemic rabbit papillary muscle. This group has also presented data on activation of the iridium sites to reduce impedances to levels suitable for their recordings. Investigators from several disciplines have been pursuing methods to use probes for recording from tissue slices, including retina and salamandar olfactory bulb.

除了经典的皮质探针应用领域外， 深层结构、周围神经和神经假体，还有 有兴趣使用探头从其他区域进行记录，包括 心肌和组织切片。 心肌，与外周肌肉一样 神经，对于硅探针来说是一个具有挑战性的准备工作，因为 穿透困难且结构的相对运动 非常大。 Cascio 博士与 Nagle 博士合作， 成功记录缺血兔的纵向激活 乳头肌。 该小组还提供了有关激活的数据 铱站点将阻抗降低到适合其的水平 录音。 来自多个学科的研究人员一直在追寻 使用探针记录组织切片的方法，包括 视网膜和蝾螈嗅球。