SERVICE: MULTICHANNEL ELECTRODES & SILICON SUBSTRATE PROBES

服务：多通道电极

• 批准号: 6505245
• 负责人: Jamille F Hetke
• 金额: $ 20.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6505245
• 关键词: Mammalia; animal tissue; bioengineering /biomedical engineering; biomaterials; biomedical equipment development; biomedical resource; medical rehabilitation related tag; nervous system; prosthesis; technology /technique

The preparation of probes for experimental use does not end with their final etch from the silicon wafer. The probes must be packaged and prepared for the particular application. Ongoing efforts in the area of packaging include development of higher density connectors, more robust cabling systems, and of improved standardization schemes. In addition to our own internal developments in all of these areas, we are also working with PI Medical in Portland, OR. Collaborations with PI and some of our probe users are resulting in usable systems which are producing the desired physiological data. We will continue to support PI Medical in their Phase II SBIR from the NIH for the development of user-ready microprobe assemblies. We are also working with several groups on the post-processing of probes. Post-processing involves the deposition of coatings on the probes after they have been etched from the wafer to improve their qualities in a specific way. One post-processing method is the deposition of parylene. This is being done by both PI Medical and the Cochlear Corp. Parylene can be used to improve the robustness of the probe shanks which permits their handling for deep insertions. The ability to selectively ablate only a small area of parylene on a large site may permit us to customize probes after they are etched from the wafer, a potentially simpler and less-costly undertaking. Another post-processing method is the deposition of biopolymers to influence tissue reaction to the probes. This work is being done by Dr. Martin at Univ. of Mich. He has coated some probes for Dr. Highstein of Washington University which have been implanted in the vestibular nerve of toadfish.

实验用探针的制备并没有结束 他们对硅晶圆进行最后的蚀刻。 探头必须包装好 并为特定应用做好准备。 持续努力 封装领域包括​​开发更高密度的连接器， 更强大的布线系统以及改进的标准化方案。 除了我们在所有这些领域的内部发展之外，我们 还与俄勒冈州波特兰市的 PI Medical 合作。 合作伙伴 PI 和我们的一些探针用户正在开发可用的系统 正在产生所需的生理数据。 我们将继续 支持 PI Medical 的 NIH II 期 SBIR 项目 开发用户就绪的微探针组件。 我们也在工作 与几个小组一起研究探针的后处理。 后处理 涉及在探头上沉积涂层 从晶圆上蚀刻，以特定方式提高其质量。 一种后处理方法是沉积聚对二甲苯。 这是 由 PI Medical 和 Cochlear Corp 共同完成。聚对二甲苯可以 用于提高探头柄的坚固性，从而允许它们 深度插入的处理。 仅选择性消融的能力 大场地上的一小块聚对二甲苯可以让我们定制 从晶圆上蚀刻后的探针，一种可能更简单且 成本较低的事业。 另一种后处理方法是 生物聚合物的沉积影响组织对探针的反应。 这项工作是由大学的马丁博士完成的。 密歇根州的。他有 为华盛顿大学的 Highstein 博士涂覆了一些探针 已被植入蟾蜍的前庭神经中。