HIGH-RESOLUTION MAGNETIC SECTOR MASS SPECTROMETER

本提案是对印第安纳大学化学系质谱设备进行仪器升级的请求。升级将包括购买具有电子冲击（EI）、化学电离（CI）、液体二次离子质谱（LSIMS）、现场解吸（FD）和电喷雾电离（ESI）能力的高分辨率磁扇区质谱仪，以支持合成化学（有机、无机和生物化学）领域的研究。目前，质谱分析设施配备了一台20年的Kratos MS80，具有EI， CI和快速原子轰击（FAB）。MS80无法分析中大型分子，因为它的旧设计（低加速电压和缺乏后加速离子检测系统）。由于电离方法的限制，许多化合物如多电荷配位配合物和多电荷生物分子等无法分析。事实上，我们系无机化学和生物化学的几个研究小组都要把这些类型的样品送到校外进行ESI数据采集。最重要的是，我们的MS80的老化部件开始例行故障。奎托斯不再为它的部门工具制造或提供足够的支持。因此，维修仪器需要较长的时间，仪器长时间的停机经常中断我系的研究工作。获得一台现代仪器以提供更好的质谱支持将大大提高印第安纳州的合成领域。这次升级将极大地提高我们表征分子样品的能力，并有望提高化学系和整个国际大学系统其他学院的研究能力。获得拟议系统的时机至关重要。

This proposal is a request for an instrument upgrade in the Mass Spectrometry Facility at Indiana University in the Department of Chemistry. The upgrade will consist of the purchase of a high-resolution magnetic sector mass spectrometer with electron impact (EI), chemical ionization (CI), liquid secondary ion mass spectrometry (LSIMS), field desorption (FD) and electrospray ionization (ESI) capabilities to support research in the area of synthetic chemistry (organic, inorganic and biochemistry). Currently the mass spectrometry facility is equipped with a single 20-year old Kratos MS80 with EI, CI and fast atom bombardment (FAB). The MS80 is incapable of analyzing medium to large sized molecules because of its old design (low accelerating voltage and lack of post acceleration ion detection system). Because of the limited ionization methods, many compounds such as multiply charged coordination complexes and multiply charged biomolecules cannot be analyzed. In fact, several research groups in inorganic chemistry and biochemistry in our department have to send these types of samples off- campus for ESI data. Most importantly, the aging components of our MS80 are beginning to fail routinely. Kratos no longer makes or provides adequate support for its sector instruments. As a result, repairing the instrument takes longer time and the prolonged instrument downtimes have frequently interrupted the research in our department. Acquiring a modern instrument to provide better mass spectrometric support will be a substantial enhancement in areas of synthesis in Indiana. This upgrade will provide tremendous improvements in our ability to characterize molecular samples and is expected to enhance research capabilities in the department of Chemistry and at other schools across the I.U. system. The timing of acquiring the proposed system is critical.