Shared Instrument Grant: Volume CT

本提案要求为MGH CT计划购买容积CT（VCT）系统提供部分支持。 建议的仪器包括一个高分辨率的全视野面板数字探测器安装到一个标准的高速螺旋CT机架。拟议的VCT系统具有特殊的空间（约150）和时间分辨率（约0.5秒）的能力。VCT系统的可用性将大大提高一组NIH资助的研究人员的研究工作。该系统可支持高分辨率（易损斑块、心肌结构、淋巴结成像和代谢骨研究的表征）和功能（心脏功能、组织灌注）成像研究。该应用程序包含11个主要项目，由代表不同学科（心脏病学、肿瘤学、神经病学、放射学和外科学）、波士顿地区机构（MGH、儿童医院和哈佛灵长类动物中心）和NIH资金来源（NCI、NHLBI、VIA、NIAMS、NINDS）的广泛用户基础组成。必要的行政和技术指导已经到位，以确保有效利用这一仪器的VCT系统，与现有的CT系统无法提供的能力，将是一个重要的资产，将是一个重大的资产，以一个社区的NIH资助的研究人员，并可能导致重大创新的成像研究。

This proposal requests partial support for the purchase of a volume CT (VCT) system for the MGH CT program. The proposed instrumentation consists of a high-resolution full-field panel digital detector mounted to a standard high-speed helical CT gantry. The proposed VCT system possesses exceptional spatial (approximately 150) and temporal resolution (approximately 0.5 sec) capabilities. The availability of the VCT system will significantly enhance the research efforts of a group of NIH funded investigators. The system can support both high resolution (characterization of vulnerable plaque, myocardial structure, lymph node imaging and metabolic bone studies) and functional (cardiac function, tissue perfusion) imaging research. The application contains eleven major projects are comprised of a broad base of users representing various disciplines (cardiology, oncology, neurology, radiology and surgery), Boston area institutions (MGH, Childrens Hospital and the Harvard Primate Center) and NIH funding sources (NCI, NHLBI, VIA, NIAMS, NINDS). The necessary administrative and technical direction is already in place to ensure efficient utilization of this instrumentation The VCT system, with capabilities not available on existing CT systems, will be a major asset, will be a major asset to a community of NIH funded investigators and likely lead to major innovations in imaging research.