SKELETAL MUSCLE--NEW BODY COMPOSITION MODELS //METHODS

骨骼肌——新的身体成分模型//方法

• 批准号: 6575630
• 负责人: STEVE HEYMSFIELD
• 金额: $ 14.86万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6575630
• 关键词: African American; adolescence (12-20); age difference; anorexia nervosa; biological models; body composition; body weight; caucasian American; child physical development; clinical research; computed axial tomography; gender difference; human subject; laboratory rat; longitudinal human study; magnetic resonance imaging; middle childhood (6-11); muscle function; muscle metabolism; normal ossification; obesity; racial /ethnic difference; statistics /biometry; striated muscles

The proposed studies are prompted by subcutaneous adipose tissue (SAT) wasting and visceral adipose tissue VAT) accumulation, plus hyperlipidemia and insulin resistance (R1) observed in HIV-infected patients receiving highly active anti-retroviral therapies. There is concern that these developments promote atherosclerosis. However, it is not clear how the body composition changes are related to the metabolic changes, which fat compartments affect RI, nor if the risks are the same in HIV and non-HIV conditions. The underlying hypothesis is that aspects of HIV infection or its treatment decrease the influence of VAT upon RI. The specific aims are, 1) To determine the effects of HIV infection upon the relationship between body fat distribution and R1; 2) To compare the effects of diet plus exercise upon fat distribution and RI in HIV-infected and uninfected women with increased VAT; 3) To compare the effects of a thiazolidinedione, rosiglitazone, upon VAT and R1 in HIV-infected and uninfected men with increased VAT. In preliminary studies, we described the phenotypic changes that occur in HIV-infected subjects, distinguished true from pseudotruncal obesity, demonstrated the influence of sex, and determined the effects of treatment with growth hormone and resistance exercise upon VAT. We also have described the effects of race, age and total fat mass upon the relationship between VAT and R1 in non-HIV infected women, assessed possible contributions of upper body SAT to RI, and made measurements of glucose disposal rate and endogenous glucose production. A total of 180 studies are planned for PPG III. Cross sectional studies will determine the effect of HIV infection upon fat distribution and RI over a wide range of VAT, while the intervention studies will be performed in subgroups of subjects with increased VAT. Studies will include composition analysis by whole body MRI, including estimation of intramyocellular lipid, and other body composition techniques, and studies of RI by euglycemic clamp technique. Safety analyses as well as other PPG III endpoints, such as quality of life, also be measured.

在接受高活性抗逆转录病毒治疗的hiv感染患者中观察到皮下脂肪组织（SAT）消耗和内脏脂肪组织（VAT）积累，以及高脂血症和胰岛素抵抗（R1），这促使了拟议的研究。人们担心这些发展会促进动脉粥样硬化。然而，目前尚不清楚身体成分的变化如何与代谢变化相关，哪些脂肪区室影响RI，也不清楚HIV和非HIV条件下的风险是否相同。潜在的假设是，HIV感染或其治疗方面降低了VAT对RI的影响。具体目的是：1)确定HIV感染对体脂分布与R1之间关系的影响；2)比较饮食加运动对VAT增加的hiv感染和未感染妇女脂肪分布和RI的影响；3)比较一种噻唑烷二酮罗格列酮对hiv感染者和未感染者VAT和R1升高的影响。在初步研究中，我们描述了hiv感染受试者的表型变化，区分了真正的假躯干肥胖，证明了性别的影响，并确定了生长激素治疗和抗阻运动对VAT的影响。我们还描述了种族、年龄和总脂肪量对非hiv感染妇女VAT和R1之间关系的影响，评估了上体SAT对RI的可能贡献，并测量了葡萄糖处置率和内源性葡萄糖生成。PPG III总共计划进行180项研究。横断面研究将确定HIV感染对VAT范围内脂肪分布和RI的影响，而干预研究将在VAT增加的受试者亚组中进行。研究将包括通过全身MRI进行成分分析，包括估计细胞内脂质和其他身体成分技术，以及通过血糖钳技术研究RI。安全性分析以及其他PPG III终点，如生活质量，也被测量。