SKELETAL MUSCLE--NEW BODY COMPOSITION MODELS //METHODS

骨骼肌——新的身体成分模型//方法

• 批准号: 6653320
• 负责人: STEVE HEYMSFIELD
• 金额: $ 14.86万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653320
• 关键词: African American; adolescence (12-20); age difference; anorexia nervosa; biological models; body composition; body weight; caucasian American; child physical development; clinical research; computed axial tomography; gender difference; human subject; laboratory rat; longitudinal human study; magnetic resonance imaging; middle childhood (6-11); muscle function; muscle metabolism; normal ossification; obesity; racial /ethnic difference; statistics /biometry; striated muscles

The proposed studies are prompted by subcutaneous adipose tissue (SAT) wasting and visceral adipose tissue VAT) accumulation, plus hyperlipidemia and insulin resistance (R1) observed in HIV-infected patients receiving highly active anti-retroviral therapies. There is concern that these developments promote atherosclerosis. However, it is not clear how the body composition changes are related to the metabolic changes, which fat compartments affect RI, nor if the risks are the same in HIV and non-HIV conditions. The underlying hypothesis is that aspects of HIV infection or its treatment decrease the influence of VAT upon RI. The specific aims are, 1) To determine the effects of HIV infection upon the relationship between body fat distribution and R1; 2) To compare the effects of diet plus exercise upon fat distribution and RI in HIV-infected and uninfected women with increased VAT; 3) To compare the effects of a thiazolidinedione, rosiglitazone, upon VAT and R1 in HIV-infected and uninfected men with increased VAT. In preliminary studies, we described the phenotypic changes that occur in HIV-infected subjects, distinguished true from pseudotruncal obesity, demonstrated the influence of sex, and determined the effects of treatment with growth hormone and resistance exercise upon VAT. We also have described the effects of race, age and total fat mass upon the relationship between VAT and R1 in non-HIV infected women, assessed possible contributions of upper body SAT to RI, and made measurements of glucose disposal rate and endogenous glucose production. A total of 180 studies are planned for PPG III. Cross sectional studies will determine the effect of HIV infection upon fat distribution and RI over a wide range of VAT, while the intervention studies will be performed in subgroups of subjects with increased VAT. Studies will include composition analysis by whole body MRI, including estimation of intramyocellular lipid, and other body composition techniques, and studies of RI by euglycemic clamp technique. Safety analyses as well as other PPG III endpoints, such as quality of life, also be measured.

建议的研究是由皮下脂肪组织（SAT）消耗和内脏脂肪组织（VAT）积累，加上高脂血症和胰岛素抵抗（R1）在接受高活性抗逆转录病毒治疗的艾滋病毒感染患者中观察到的。人们担心这些发展会促进动脉粥样硬化。然而，目前尚不清楚身体成分的变化如何与代谢变化相关，哪些脂肪区室影响RI，也不清楚HIV和非HIV条件下的风险是否相同。潜在的假设是，艾滋病毒感染或其治疗的方面减少增值税后RI的影响。具体目的是：1）确定HIV感染对体脂分布和R1之间关系的影响; 2）比较饮食加运动对VAT增加的HIV感染和未感染女性的脂肪分布和RI的影响; 3）比较噻唑烷二酮罗格列酮对VAT增加的HIV感染和未感染男性的VAT和R1的影响。在初步研究中，我们描述了发生在HIV感染受试者的表型变化，区分真正的假性躯干肥胖，证明了性别的影响，并确定了治疗与生长激素和阻力运动后增值税的影响。我们还描述了种族，年龄和总脂肪量的影响后，VAT和R1之间的关系，在非HIV感染的妇女，评估可能的贡献上身SAT RI，并进行测量的葡萄糖处置率和内源性葡萄糖的生产。PPG III计划共进行180项研究。横断面研究将确定HIV感染对脂肪分布和RI在广泛的VAT范围内的影响，而干预研究将在VAT增加的受试者亚组中进行。研究将包括通过全身MRI进行的成分分析，包括肌细胞内脂质估计和其他身体成分技术，以及通过正葡萄糖钳夹技术进行的RI研究。还应测量安全性分析以及其他PPG III终点，如生活质量。