Core--Pulmonary function testing unit

核心--肺功能检测单元

• 批准号: 6656492
• 负责人: EDWARD S SCHELEGLE
• 金额: $ 15.72万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-04 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656492
• 关键词: Macaca mulatta; allergens; biomedical facility; disease /disorder model; dosage; model design /development; pollution related respiratory disorder; respiratory airflow measurement; respiratory airway clearance; respiratory airway volume; respiratory function

The critical procedures in this unit are measurements of airway resistance, breathing frequency, and tidal volume, and administering the test for airway hyperresponsiveness for specific allergen, HDMA and nonspecific (methacholine, phenyl biquanine) challenges. These data will be expressed as CDA 200 or EC 200 Raw, the concentration or dose of challenge needed to double airway resistance. Raw will be measured using Transfer Impedance which involves an established model of airway mechanics to predict airway resistance from wave forms generated by acoustical speakers. The wave forms are sensitive to changes in airway caliber and are determined from the pressure recordings in the pleythsmograph box and the airway flow recorded in pneumotchograph connected to the monkey by a face mask or endotracheal tube.

本单元的关键步骤是测量气道 阻力、呼吸频率和潮气量，并进行测试 对于特异性变应原、HDMA和非特异性变应原的气道高反应性， （乙酰甲胆碱，苯基双喹）挑战。这些数据将表示为 CDA 200或EC 200 Raw，需要加倍的攻毒浓度或剂量 气道阻力将使用传输阻抗测量原始数据， 涉及气道力学的建立模型以预测气道阻力 由扬声器产生的波形。波形是 对气道口径的变化敏感， 记录在脉搏波描记器盒中， 通过面罩或气管内导管连接到猴子的呼吸描记器。