Core--Pulmonary function testing unit

本单元的关键步骤是测量呼吸道。 阻力、呼吸频率和潮气量，并进行测试 针对特定过敏原、HDMA和非特异性过敏原的呼吸道高反应性 (乙酰甲胆碱、苯基联喹)挑战。这些数据将表示为 CDA 200或EC 200 Raw，需要加倍的挑战浓度或剂量 呼吸道阻力。RAW将使用传递阻抗进行测量，传递阻抗 使用已建立的呼吸道力学模型来预测呼吸道阻力 从声学扬声器产生的波形。这些波形是 对呼吸道口径的变化敏感，并由压力确定 记录在心搏图盒中的记录和记录在 通过面罩或气管插管连接到猴子身上的气体记录仪。

The critical procedures in this unit are measurements of airway resistance, breathing frequency, and tidal volume, and administering the test for airway hyperresponsiveness for specific allergen, HDMA and nonspecific (methacholine, phenyl biquanine) challenges. These data will be expressed as CDA 200 or EC 200 Raw, the concentration or dose of challenge needed to double airway resistance. Raw will be measured using Transfer Impedance which involves an established model of airway mechanics to predict airway resistance from wave forms generated by acoustical speakers. The wave forms are sensitive to changes in airway caliber and are determined from the pressure recordings in the pleythsmograph box and the airway flow recorded in pneumotchograph connected to the monkey by a face mask or endotracheal tube.