The neurophysiology of shape and spatial working memory

形状和空间工作记忆的神经生理学

• 批准号: 6639237
• 负责人: ANNE B SERENO
• 金额: $ 22.31万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6639237
• 关键词: Macaca mulatta; behavior test; behavioral /social science research tag; computer data analysis; electrodes; form /pattern perception; histology; neurophysiology; prefrontal lobe /cortex; short term memory; single cell analysis; space perception; temporal lobe /cortex

DESCRIPTION(adapted from applicant's abstract): This proposal examines two kinds of working memory-memory for shape and space- at the cellular level using a single unit recording technique in awake behaving rhesus monkeys. Much work suggests that perceptual processing proceeds along two cortical paths in temporal and parietal cortices, often characterized as the 'what' and where pathways, respectively. Both pathways project to regions of prefrontal cortex. Previous work has not been careful in the manipulation of featural and spatial working memory requirements and no study has compared cell response to both kinds of working memory within the same cortical area with identical visual conditions. Using the proposed paradigms, we have just finished recording from posterior parietal and inferior temporal cortices of animals performing these tasks where we found quite different patterns of findings. This study will provide valuable information as to whether working memory of shape and space are physiologically segregated in prefrontal cortex. We will also be able to report exactly how these types of working memory modulate cell response and how this relates to the sensory and motor response of the cell. Further, we will be able to compare the findings directly to data we have obtained from posterior parietal and inferior temporal cortices. Prefrontal cortex has been implicated in a variety of human neurological and mental diseases, including Parkinson's disease. Huntington's chorea, Korsakoff's disease, and schizophrenia. Little work in the neuropsvchology of memory has focused on short-term or working memory. Characterization of mechanisms related to working memory in prefrontal cortex may prove useful for better understanding what role short-term or working memory deficits play in the cognitive and psychiatric abnormalities that are associated with these conditions.

描述(改编自申请人的摘要)：这份提案审查了两个 各种工作记忆-形状和空间记忆-在细胞水平上使用 恒河猴清醒行为的单单位记录技术。工作量很大 提示知觉加工在大脑中沿着两条皮质路径进行。 颞叶和顶叶皮质，通常被描述为“什么”和“在哪里” 分别是路径。这两条通路都投射到前额叶皮质区域。 以前的工作在要素和空间的处理上并不仔细 工作记忆的需求，没有研究比较细胞对两者的反应 同一大脑皮层区域内视觉相同的各种工作记忆 条件。使用建议的范例，我们刚刚完成了来自 完成这些任务的动物的顶后皮质和颞叶下部皮质 任务中，我们发现了完全不同的发现模式。这项研究将 提供有价值的信息，关于形状和空间的工作记忆 在前额叶皮质生理上是分开的。我们还将能够 准确地报告这些类型的工作记忆如何调节细胞反应以及如何 这与细胞的感觉和运动反应有关。此外，我们还将 能够直接将结果与我们从后验获得的数据进行比较 顶叶和颞叶下部皮质。前额叶皮质被牵连到 在各种人类神经和精神疾病中，包括帕金森氏症 疾病。亨廷顿舞蹈病、科萨科夫病和精神分裂症。一点儿 关于记忆的神经心理学的研究一直集中在短期或工作上 记忆。前额叶工作记忆相关机制的表征 皮质可能被证明有助于更好地理解短期或 工作记忆缺陷在认知和精神异常中起作用 与这些情况相关的基因。