The neurophysiology of shape and spatial working memory

描述（改编自申请人的摘要）：本提案审查了两个 各种工作记忆-形状和空间记忆-在细胞水平上使用 在清醒状态的恒河猴中进行的一种单一单元记录技术。许多工作 表明知觉处理过程沿着沿着两条皮层路径进行， 颞叶和顶叶皮层，通常被描述为"什么"和"在哪里" 路，分别。这两条通路都投射到前额皮质区域。 以前的工作在特征和空间的操作上并不小心 工作记忆的要求，没有研究比较细胞反应， 在同一个皮层区域内，具有相同的视觉功能， 条件使用所提出的范例，我们刚刚完成了从 后顶叶和下颞叶皮质的动物执行这些 我们发现了完全不同的发现模式。本研究将 提供有关形状和空间的工作记忆是否 在前额叶皮层中是生理隔离的。我们也将能够 准确地报告了这些类型的工作记忆是如何调节细胞反应的， 这涉及细胞的感觉和运动反应。此外，我们将 能够直接将研究结果与我们从后验分析中获得的数据进行比较， 顶叶和下颞叶皮层前额叶皮层与 包括帕金森氏症在内的多种人类神经和精神疾病 疾病亨廷顿舞蹈病，科萨科夫病，精神分裂症。小 记忆神经心理学的研究主要集中在短期或工作 记忆前额叶工作记忆相关机制的表征 大脑皮层可能有助于更好地理解短期或长期的作用， 工作记忆缺陷在认知和精神异常中起作用 与这些疾病相关的疾病

DESCRIPTION(adapted from applicant's abstract): This proposal examines two kinds of working memory-memory for shape and space- at the cellular level using a single unit recording technique in awake behaving rhesus monkeys. Much work suggests that perceptual processing proceeds along two cortical paths in temporal and parietal cortices, often characterized as the 'what' and where pathways, respectively. Both pathways project to regions of prefrontal cortex. Previous work has not been careful in the manipulation of featural and spatial working memory requirements and no study has compared cell response to both kinds of working memory within the same cortical area with identical visual conditions. Using the proposed paradigms, we have just finished recording from posterior parietal and inferior temporal cortices of animals performing these tasks where we found quite different patterns of findings. This study will provide valuable information as to whether working memory of shape and space are physiologically segregated in prefrontal cortex. We will also be able to report exactly how these types of working memory modulate cell response and how this relates to the sensory and motor response of the cell. Further, we will be able to compare the findings directly to data we have obtained from posterior parietal and inferior temporal cortices. Prefrontal cortex has been implicated in a variety of human neurological and mental diseases, including Parkinson's disease. Huntington's chorea, Korsakoff's disease, and schizophrenia. Little work in the neuropsvchology of memory has focused on short-term or working memory. Characterization of mechanisms related to working memory in prefrontal cortex may prove useful for better understanding what role short-term or working memory deficits play in the cognitive and psychiatric abnormalities that are associated with these conditions.