Use and Outcome of Total Joint Replacement in Hispanics

全关节置换术在西班牙裔中的应用和结果

• 批准号: 6645507
• 负责人: AGUSTIN ESCALANTE
• 金额: $ 13.63万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-06 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645507
• 关键词: Hispanic Americans; Medicare /Medicaid; age difference; culture; depression; functional ability; gender difference; health care service utilization; hip prosthesis; human population study; human subject; interview; longitudinal human study; orthopedics; outcomes research; pain; patient oriented research; person with disability; postoperative state; preoperative state; quality of life; questionnaires; rheumatoid arthritis; social psychology; statistics /biometry

DESCRIPTION (Taken from the applicants abstract): The candidate for this K-24 award has a track record of funding and publications that demonstrate his commitment to a career in patient-oriented research. The award will give him a period of intense focus on the 2 central research themes of his career: (1) Utilization and outcomes of total joint replacement among U.S. Hispanics; and (2) The disablement process in rheumatoid arthritis (RA). The first research project has 3 specific aims: 1) To determine, in the Medicare population, whether recipients of a primary total hip replacement are as likely to be Hispanic, as are age-, sex- and county of residence-matched controls; 2) To determine to what extent preoperative functional status differs between Hispanics and non-Hispanics having a joint replacement in Bexar County, Texas; and 3) To determine how preoperative functional status affects the outcome of joint replacement. The second project will test a biopsychosocial model of the disablement process in a cohort of 770, mostly Mexican American RA patients. Its 4 specific aims are 1) To define the sequence of events in disability due to articular damage; 2) To define the sequence of events due to pain; 3) To define the sequence related to depression; and 4) To determine to what extent the cultural and genetic characteristics of Mexican Americans influence the disablement process in RA. The award will also allow the candidate to build on his record of mentoring, with 5 outstanding junior investigators that have committed to work with him at his institution. Their levels of training range from an Internal Medicine resident pursuing a research pathway for Board Certification, to 2 new Assistant Professors who will collaborate on the candidates research. All 5 of them will participate in a formal clinical research training program developed by the candidate. The research and mentoring activities of this K24 awards will benefit from an outstanding environment that is highly favorable to patient-oriented research. Elements of this environment include: existence of sufficient funding to conduct the research; an established research team with experience studying the predominantly Mexican American population of the region; an NCRR-supported General Clinical Research Center; and an exceptional group of collaborators and consultants with expertise in epidemiology, research methods and biostatistics, all of whom have a record of collaboration with the candidate. With this K24 award, the candidate will extend what is known about the utilization of !joint replacements by Hispanics in the U.S., and will advance understanding of the influence of genetic, clinical and psychosocial factors in the outcome of PA. His mentoring role will also help create a critical mass of investigators focused on arthritis-related disability among the U.S. Hispanic population.

描述（取自申请人摘要）：该K-24奖的候选人具有资金和出版物的记录，证明了他的 致力于以患者为导向的研究。该奖项将给他一个 强烈关注他职业生涯的两个中央研究主题的时期：（1） 美国西班牙裔美国人中联合替代的利用和结果；和 （2）类风湿关节炎（RA）的残疾过程。第一个研究 项目具有3个具体目标：1）确定医疗保险人口 主要的总髋关节置换者是否有可能 西班牙裔，年龄，性别和居住县匹配的对照； 2）到 确定术前功能状态在多大程度上有所不同 西班牙裔和非西班牙裔在德克萨斯州的贝克萨尔县联合替代； 3）确定术前功能状态如何影响 关节更换。第二个项目将测试一个生物心理社会模型 在770人的队列中，主要是墨西哥裔美国人RA患者。 它的4个具体目标是1）定义应付残疾事件的顺序 关节损害； 2）定义因疼痛引起的事件的顺序； 3）到 定义与抑郁有关的序列； 4）确定在多大程度上 墨西哥裔美国人的文化和遗传特征影响 RA中的残疾过程。该奖项还将允许候选人建立 他的指导记录，有5位出色的初级调查员 致力于在他的机构与他合作。他们的训练水平 从居民追求董事会研究途径的居民 认证，向2名新助理教授合作 候选人研究。他们中的所有5个都将参加正式的临床 候选人制定的研究培训计划。研究和 这项K24奖项的指导活动将受益于杰出的 非常有利于患者研究的环境。元素 这个环境包括：有足够的资金来进行 研究;一个知名的研究团队，具有研究的经验 该地区主要是墨西哥裔美国人人口； NCRR支持 一般临床研究中心；以及一个杰出的合作者和 具有流行病学，研究方法和生物统计学专业知识的顾问， 所有人都有与候选人合作的记录。使用此K24 奖励，候选人将扩展有关！ 西班牙裔在美国的替代者，并将促进对 遗传，临床和社会心理因素对PA结果的影响。 他的指导角色还将有助于创造大量的调查员 专注于美国西班牙裔人群中与关节炎相关的残疾。