QUANTITATIVE CARDIAC PHYSIOLOGY IN CLINICAL CARDIOLOGY

临床心脏病学中的定量心脏生理学

• 批准号: 6613392
• 负责人: Sandor J. Kovacs
• 金额: $ 8.3万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6613392
• 关键词: bioimaging /biomedical imaging; blood pressure; clinical research; diagnosis design /evaluation; diagnostic catheterization; echocardiography; gender difference; heart catheterization; heart failure; heart rate; human mortality; human old age (65+); human subject; image processing; longitudinal human study; magnetic resonance imaging; noninvasive diagnosis; outcomes research; prognosis; racial /ethnic difference; statistics /biometry

This revised application for a Midcareer Investigator Award in Patient- Oriented Research focuses on quantitative cardiac physiology in clinical cardiology. The goal is to mentor young investigators in multi- disciplinary clinical investigation aimed at maximizing the amount of useful information extracted. The applicant has an established record of mentoring. In 1991 he founded Washington University's Cardiovascular Biophysics Laboratory in part to serve as a training and hypothesis- testing venue for patient-oriented research. Trainees will be exposed to ongoing investigations that use novel methods to explore mechanisms of human disease (congestive heart failure, systolic and diastolic dysfunction) and elucidate physiology (four-chamber heart function). Main themes of investigations include: diastolic function assessment by Doppler echocardiography via model-based image processing (MBIP); four chamber equilibrium volume determination by cardiac MRI; and hemodynamic characterization by phase-plane analysis. The intrinsically multi-disciplinary methods include clinical, cognitive, and quantitative tools for testing causal and correlative hypotheses. Trainees' support is via the Cardiovascular Division's training grant (NIH: 5-T32-HL07081, M.E. Cain, PI). They will formulate hypotheses that require quantitative characterization of cardiac physiology via acquisition and processing of multi-channel physiological data, and test them via application of statistical methods and determination of clinical correlates. As part of the Research Plan, one completed, funded, retrospective pilot project and its natural prospective extension are described in which trainees will participate. The hypothesis project and its natural prospective extension are described in which trainees will participate. The hypothesis tested is that Doppler derived indexes of diastolic function generated by MBIP (a novel approach) are better indicators of 1-year mortality in selected elderly patients admitted to the hospital with heart failure than are conventional echocardiographic indexes (EF, deceleration time) from the same Doppler data.

这项修订后，在以患者为导向的研究中获得的中级研究员奖的申请重点介绍了临床心脏病学的定量心脏生理。目的是指导年轻研究人员进行多学科临床研究，以最大程度地提取有用信息。申请人拥有既定的指导记录。 1991年，他创立了华盛顿大学的心血管生物物理学实验室，部分是用于以患者为导向的研究的培训和假设测试场所。学员将接受正在进行的研究，这些调查使用新方法来探索人类疾病的机制（充血性心力衰竭，收缩和舒张功能障碍）和阐明生理学（四腔心脏功能）。研究的主要主题包括：通过基于模型的图像处理（MBIP）通过多普勒超声心动图评估舒张功能评估；通过心脏MRI测定四个腔室平衡体积；和通过相平面分析进行血液动力学表征。本质上多学科的方法包括用于检验因果和相关假设的临床，认知和定量工具。受训人员的支持是通过心血管师的培训补助金（NIH：5-T32-HL07081，M.E。Cain，PI）。他们将提出假设，需要通过获取和处理多通道生理数据对心脏生理的定量表征，并通过应用统计方法和确定临床相关性来测试它们。作为研究计划的一部分，描述了一个完成，资助，回顾性的试点项目及其自然的潜在扩展，在该计划中，学员将参加。描述了该假设项目及其自然的预期扩展，学员将参加。所检验的假设是，MBIP产生的舒张功能（一种新方法）的多普勒衍生的索引比传统的超声心动图指数（EF，减速时间）从同一多普勒数据中更好地指示了患有心力衰竭的选定的老年患者的1年死亡率指标。