MODEL BASED IMAGE PROCESSING IN DOPPLER ECHOCARDIOGRAPHY

描述(改编自申请者摘要)：申请者有 在不同制造商的超声心动图设备上开发和测试， 基于模型的图像处理(MBIP)技术在舒张期分析中的应用 二尖瓣血流速度图。该方法可以提取出 来自二尖瓣多普勒的定量生理信息 以前无法获得或只能获得的超声心动图图像 由心导管检查确定。这项拟议的研究遵循两项 主要的、相互关联的主题：一)改进MBIP方法和，二) 体内验证。具体地说，以下是MBIP步骤 精细化：1)视频采集非机器多谱勒图像 抓帧，2)最大速度轮廓提取，3)拟合 用数字处理方法求解左心室充盈模型的等高线， 估计理论和误差最小化。体内组件将测试 假设生理上相关的，非侵入性的量化 通过这种MBIP方法可以实现DF。MBIP的优势，与 可用的多普勒分析方法包括：1)与回波机无关， 数字确定的，而不是手写跟踪/手写数字化的多普勒 速度等值线，2)因果建模，而不是相关建模，3) 由数值(自动)方法确定的唯一值模型参数 直接从多普勒图像，4)非侵入性地确定DF参数 以前需要做导尿术。拟议的研究将确定 通过二尖瓣多普勒超声心动图获得生理df参数， 并通过同时进行左心和右心插管来验证它们 符合纳入标准的受试者。具体目标是：1) 改进和扩展心脏舒张期多普勒分析的MBIP方法，2) 验证MBIP派生指数与入侵派生指数之间的关系 同时舒张期多谱勒和高保真分析测向 血流动力学数据和基于MBIP的预测，3)验证生理 作为临床相关多普勒衍生指标的MBIP参数的类似物 Df.

DESCRIPTION (Adapted from Applicant's Abstract): The applicants have developed and tested, on various manufacturers' echocardiography equipment, a model-based image processing (MBIP) method for the analysis of diastolic transmitral Doppler flow velocity images. The method can extract quantitative physiologic information from transmitral Doppler echocardiographic images that previously could not be obtained or could only be determined by cardiac catheterization. The proposed research follows two main, interconnected themes: I) refinement of the MBIP method and, II) in-vivo verification. Specifically, the following MBIP steps will be refined: 1) machine independent Doppler image acquisition via video frame-grabbing, 2) extraction of the maximum velocity contour, and 3) fit solution of LV filling model to the contour using digital processing, estimation theory and error minimization. The in-vivo component will test the hypothesis that physiologically relevant, non-invasive quantitation of DF can be achieved by this MBIP method. MBIP advantages, in comparison to available methods of Doppler analysis include: 1) echo machine independent, numerically determined, rather than hand-traced/hand-digitized Doppler velocity contours, 2) causal, rather than correlative modeling, 3) unique-valued model parameters determined by numerical (automated) means directly from Doppler images, 4) noninvasive determination of DF parameters previously requiring catheterization. The proposed research will identify physiologic DF parameters obtained by transmitral Doppler echocardiography, and verify them, by simultaneous left and right heart catheterization in subjects meeting inclusionary criteria. The Specific Aims are to: 1) refine and extend the MBIP method for cardiac diastolic Doppler analysis, 2) validate the relation between MBIP-derived and invasively-derived indices of DF by analysis of simultaneous diastolic Doppler and high-fidelity hemodynamic data and MBIP based predictions, 3) verify the physiologic analogues of MBIP parameters as clinically relevant Doppler-derived indexes of DF.