CLINICAL RESEARCH TRAINING PROGRAM

加州大学旧金山分校提供临床研究方法方面的培训已超过15年。每年有近100名来自不同专业的研究员、住院医师和初级教员参加我们的入门研讨会，15-17人在我们为期8个月的临床研究高级培训计划中接受额外指导。加州大学旧金山分校拥有培训临床研究人员的非凡资源。我们有76名来自不同专业的教职员工，他们积极参与临床研究，并将作为讲师参加我们的课程。加州大学旧金山分校的四所学校(医学、护理、牙科和药学)在NIH资助的全国排名前三。学员可以访问加州大学伯克利分校的三个临床研究中心，以及许多正在进行的项目、来自先前工作的大型数据集，以及来自加州大学伯克利分校的公共卫生学院、Kaiser Permanente研究部门、旧金山公共卫生部以及ChIron和Genentech公司等合作机构的生物标本存储库。利用这些资源，我们建议大幅扩展临床研究训练，增设11个新的或大幅扩充的课程，并设立两个正式的训练轨道。我们建议提供一个新的两年制临床研究硕士学位(MCR)，需要36个四分之一小时的教学课程，发表一篇原始的科学论文来代替硕士论文，并与积极参与临床研究的教师导师建立牢固的导师关系。除了每年8-12名参加MCR计划的学生外，我们预计40-50名学生将攻读新的临床研究证书(CCR)，这将需要完成5门课程。我们将向其他机构分发我们的教材，并将对我们的培训活动和我们在主要目标上取得成功的程度进行评估，培养出成功的临床研究人员。我们的毕业生将能够在不断变化的临床研究世界中进行创造性和严谨的临床调查。他们将准备转化基础科学的激动人心的进步，利用信息学革命来提高临床研究的效率和能力，系统地综合临床研究的积累实体，响应对具有成本效益的医疗保健的呼吁，并在工作中保持最高的道德标准。加州大学旧金山分校和合作机构的非凡资源与扩展的课程相结合，将为临床研究的新时代培养出领先的科学家。

UCSF has provided training in the methods of clinical research for more than 15 years. Each year nearly 100 fellows, residents and junior faculty from diverse specialties take our introductory workshops, and 15-17 receive additional instruction in our 8- month Advanced Training in Clinical Research program. UCSF has extraordinary resources for training clinical investigators. We have 76 faculty members from diverse specialties who are actively involved in clinical research and will participate as instructors in our courses. All four UCSF Schools (Medicine, Nursing, Dentistry and Pharmacy) rank in the top 3 nationally for NIH funding. Trainees have access to three Clinical Research Centers at UCSF, and to numerous on-going projects, large data sets from prior work, and repositories of biological specimens drawn from UCSF and collaborating institutions including the School of Public Health at UC Berkeley, Kaiser Permanente Division of Research, the San Francisco Department of Public Health, and Chiron and Genentech Corporations. Taking advantage of these resources, we propose to greatly expand Clinical Research Training by adding 11 new or considerably enlarged courses and establishing two formal training tracks. We propose to offer a new 2-year Master of Clinical Research degree (MCR) requiring 36 quarter-hours of didactic courses, publication of an original scientific paper in lieu of a Master's thesis, and strong preceptor relationships with faculty mentors actively involved in clinical research. In addition to the 8-12 students who will enter the MCR program each year, we anticipate that 40- 50 will pursue a new Certificate in Clinical Research (CCR) that will require completion of 5 courses. We will disseminate our teaching materials to other institutions, and will carry out evaluations of our training activities and of the degree to which we succeed in the main objective, producing successful clinical investigators. Our graduates will be able to conduct creative and rigorous clinical investigation in the changing world of clinical research. They will be prepared to translate the exciting advances of basic science, capitalize on the revolution in informatics to increase the efficiency and capacity of clinical research, systematically synthesize the accumulating body of clinical research, respond to the call for cost-effective health care, and maintain the highest ethical standards in their work. The combination of the extraordinary resources of UCSF and partner institutions and the expanded curriculum will produce leading scientists for the new era of clinical investigation.