Quantification of Blood Volume Flow Using Ultrasound

描述（由申请人提供）：本提案的目标是开发， 分析和测试用于测量血流量的创新技术 超声波体积流量的量化对于许多应用是有用的。 临床应用，包括心输出量的估计、 脑血管疾病和胎儿宫内生长受限的评估 （IUGR）在怀孕期间。目前用于测量体积流量的技术是 侵入性（即插入Swan-Ganz导管）或有限 精确度（即基于多普勒测量的计算）。长期目标 该项目的目的是定义实时、与角度无关的体积流量 可以用当前临床扫描仪实现的测量技术 架构 所提出的算法将操纵多普勒与 原始超声RF信号，以计算三维矢量速度分布， 使用单个换能器的血管。法向流分量的积分 容器的横截面提供总体积流量。本研究将 使用修改的脉冲序列和数字调制器的测试实现 目前用于标准多普勒超声机。 该算法将在稳态仿血流上得到初步验证 幻影中的液体将使用排列测试来确定最佳 参数设置和过滤方案。脉搏波波形和速度 将检查生理范围的准确性和时间分辨率。 将通过测量犬的血流来进行体内技术验证 并与电磁流量袖带结果进行比较。最终评价 这项技术的一部分将涉及一项初步研究， 接受透析的受试者。

DESCRIPTION (Provided by Applicant): The goal of this proposal is to develop, analyze, and test an innovative technique for measuring volume blood flow ultrasonically. The quantification of volumetric flow is useful for a number of clinical applications including estimation of cardiac output, monitoring of cerebrovascular diseases, and evaluation of intrauterine growth restriction (IUGR) during pregnancy. Current techniques for measuring volumetric flow are either invasive (i.e. insertion of a Swan-Ganz catheter) or have limited accuracy (i.e. calculations based on Doppler measurements). The long term goal of this project is to defme a real-time, angle-independent volumetric flow measurement technique that can be implemented with current clinical scanner architecture. The proposed algorithm incorporates steered Doppler with the decorrelation of the raw ultrasound RF signals to compute the 3-D vector velocity profile of a vessel using a single transducer. Integration of the normal flow component over a cross-section of the vessel provides the total volume flow. This study will test implementation using modified pulsing sequences and digital correlators currently used in standard Doppler ultrasound machines. The algorithm will initially be verified on steady flow of blood-mimicking fluids in phantoms. A permutation test will be used to determine optimal parameter settings and ifitering schemes. Pulsatile waveforms and velocities in physiological ranges will be examined for accuracy and temporal resolution. Validation of the technique in vivo will be done by measuring flow in canine arteries and comparing with electromagnetic flow cuff results. Final evaluation of the technique will involve a pilot study quantifying flow in grafts of human subjects undergoing dialysis.