Quantification of Blood Volume Flow Using Ultrasound

描述(由申请人提供)：本提案的目标是开发、 分析和测试一种测量体积血流量的创新技术 超音波。体积流量的量化对于许多 临床应用包括心输出量的估计，监测 脑血管疾病与胎儿宫内生长受限的评估 (IUGR)在怀孕期间。目前测量体积流量的技术有 要么是有创的(即插入Swan-Ganz导管)，要么是有限的 精确度(即基于多普勒测量的计算)。长期目标 这个项目的目的是定义一个实时的、角度无关的体积流 可用现有临床扫描仪实现的测量技术 建筑。 该算法结合了定向多普勒解相关算法。 原始超声射频信号用于计算三维矢量速度分布 使用单一换能器的容器。正常流动组件的积分超过 血管的横截面提供了总体积流量。这项研究将 使用修改的脉冲序列和数字相关器的测试实现 目前用于标准的多普勒超声机。 该算法将在模拟血液的稳定流动上进行初步验证 幻影中的液体。将使用排列测试来确定最优 参数设置和开挖方案。脉动的波形和速度 将检查生理范围的准确性和时间分辨率。 这项技术的体内验证将通过测量犬体内的血流来完成 并与电磁血流袖带结果进行比较。最终评估 这项技术的一项初步研究将量化人体移植物中的血流。 接受透析的受试者。

DESCRIPTION (Provided by Applicant): The goal of this proposal is to develop, analyze, and test an innovative technique for measuring volume blood flow ultrasonically. The quantification of volumetric flow is useful for a number of clinical applications including estimation of cardiac output, monitoring of cerebrovascular diseases, and evaluation of intrauterine growth restriction (IUGR) during pregnancy. Current techniques for measuring volumetric flow are either invasive (i.e. insertion of a Swan-Ganz catheter) or have limited accuracy (i.e. calculations based on Doppler measurements). The long term goal of this project is to defme a real-time, angle-independent volumetric flow measurement technique that can be implemented with current clinical scanner architecture. The proposed algorithm incorporates steered Doppler with the decorrelation of the raw ultrasound RF signals to compute the 3-D vector velocity profile of a vessel using a single transducer. Integration of the normal flow component over a cross-section of the vessel provides the total volume flow. This study will test implementation using modified pulsing sequences and digital correlators currently used in standard Doppler ultrasound machines. The algorithm will initially be verified on steady flow of blood-mimicking fluids in phantoms. A permutation test will be used to determine optimal parameter settings and ifitering schemes. Pulsatile waveforms and velocities in physiological ranges will be examined for accuracy and temporal resolution. Validation of the technique in vivo will be done by measuring flow in canine arteries and comparing with electromagnetic flow cuff results. Final evaluation of the technique will involve a pilot study quantifying flow in grafts of human subjects undergoing dialysis.