ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA

先兆子痫的内皮屏障功能

• 批准号: 6617921
• 负责人: YUPING WANG
• 金额: $ 21.75万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-24 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6617921
• 关键词: cadherins; cell adhesion; disease /disorder etiology; female; human tissue; intercellular connection; mixed tissue /cell culture; patient oriented research; placenta; preeclampsia; trophoblast; vascular endothelium; vascular endothelium permeability

DESCRIPTION: (Adapted from the Investigator's Abstract): The researchers will 1) demonstrate the altered epithelial integrity associated with preeclampsia that is characterized by diminished barrier function and increase intracellular permeability; 2) determine how placenta-derived factors mediate the epithelial barrier dysfunction of preeclampsia; and 3) identify the cellular mediators that are responsible for the altered endothelial integrity mediated by placental factors in preeclampsia.

描述：（改编自研究者摘要）：研究人员将 1)表明与先兆子痫相关的上皮完整性改变 其特征在于屏障功能减弱， 2）确定胎盘源性因子如何介导上皮细胞 先兆子痫的屏障功能障碍;和3）鉴定细胞介质 它们负责改变内皮细胞的完整性， 先兆子痫的胎盘因素。