ACTIVATION OF TONGUE MUSCLES IN OBSTRUCTIVE SLEEP APNEA

阻塞性睡眠呼吸暂停中舌肌的激活

• 批准号: 6627561
• 负责人: DOMINIQUE M DURAND
• 金额: $ 15.3万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6627561
• 关键词: bioengineering /biomedical engineering; decerebration; dogs; electrostimulus; fiber optics; hypoglossal nerve; medical implant science; neuroimaging; neuromuscular stimulator; respiratory airflow disorder; sleep apnea; technology /technique development; tongue

DESCRIPTION:(adapted from applicant's abstract) This project aims to develop an experimental therapy for obstructive sleep apnea (OSA) using electrical stimulation of the hypoglossal nerve. The PI proposes to use a multi-channel stimulation technique for selective activation of portions of the hypoglossal nerve to activate individual tongue muscles selectively. Such stimulation might increase control over the tongue muscles and improve efficiency for electrical stimulation to remove pharyngeal obstruction. There are 3 aims to be tested in dogs. Aim 1 will determine the maximum muscle selectivity that can be obtained with a multi-contact electrode on the hypoglossal nerve. Aim 2 will evaluate the mechanical dilation of the airways due to selective stimulation. Aim 3 will determine the optimum electrode geometries and stimulation paradigms for airway dilation in chronic dogs. It is anticipated that the experimental delineation and validation of these methods will lead to a design of a neuroprosthetic device for the treatment of OSA.

描述：(改编自申请者摘要) 该项目旨在开发一种治疗阻塞性睡眠的实验性疗法。 呼吸暂停(OSA)，使用电刺激舌下神经。《少年派》 建议使用多通道刺激技术进行选择性激活 舌下神经的一部分来激活个别舌肌 有选择地。这样的刺激可能会增加对舌肌的控制 提高电刺激摘除咽部的效率 障碍物。有3个目标需要在狗身上进行测试。目标1将决定 使用多触点电极可以获得最大的肌肉选择性 在舌下神经上。目标2将评估机械扩张的 航空公司由于选择性刺激。目标3将确定最优 慢性阻塞性肺疾病患者气道扩张的电极构型和刺激模式 狗。预计实验描述和验证 这些方法将导致一种神经假体装置的设计 阻塞性睡眠呼吸暂停综合征的治疗。