Seizure control by electric field control
通过电场控制进行咬合控制
基本信息
- 批准号:10641916
- 负责人:
- 金额:$ 39.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAntiepileptic AgentsBrainCharacteristicsChronicClosure by clampCommunicationComputer ModelsComputer SimulationCouplingDataElectrodesElectrophysiology (science)EpilepsyExtracellular SpaceFocal SeizureFurosemideGenerationsGoalsHippocampusHumanImageIn VitroIronKainic AcidLaboratoriesMediatingMembraneMethodologyMethodsModelingNerve BlockNeuronsOsmolar ConcentrationPartial EpilepsiesPatientsPharmaceutical PreparationsPlayPreparationRecurrenceResearchResistanceRodentRoleSeizuresSystemTechniquesTechnologyTemporal Lobe EpilepsyTestingTissuesTravelTreatment Efficacyalternative treatmentdesignefficacy testingelectric fieldexperimental studyextracellularin vivoneuralneuroimagingneurotechnologynew technologynovelnovel strategiesnovel therapeuticsoptogeneticspreventrecruitvoltagevoltage clamp
项目摘要
Abstract
A seizure is an abnormal neural activity in the brain and the main characteristic of epilepsy. About one-third of
the patients have seizures resistant to anti-epileptic medication and therefore, an alternative treatment is
necessary. Recent studies show that neurons can be recruited and seizures can propagate by a mechanism
known as electric field coupling. Our laboratory has shown that canceling the electric field in the extracellular
space can prevent neural propagation and recruitment. We now propose to develop a novel neurotechnology
that not only can control the propagation of seizures but prevent the seizure from being generated by controlling
the extracellular electric field. With a combined methodology of in-vitro electrophysiology with state-of-the-art
neural imaging, computer modeling and in-vivo preparations in rodents, we will implement the seizure control
system and study its mechanism with four specific aims: 1) Prevent neuronal synchronization in hyperexcitable
neural tissue, 2) Develop a novel technology of extracellular voltage clamp to control seizures in-vivo, 3)
Determine the mechanisms of seizure control by an extracellular voltage clamp system, 4) Determine the role of
the extracellular space in the clamping efficiency. Current electrical responsive control therapy detects a seizure
and then applies stimulation. The proposed neurotechnology will prevent the synchronization between neurons
to stop the generation of seizures before they arise at very low current amplitude thereby providing a novel
therapeutic paradigm for treating epilepsy.
摘要
癫痫发作是大脑中的一种异常神经活动,也是癫痫的主要特征。大约三分之一的人
患者癫痫发作对抗癫痫药物有抵抗力,因此,另一种治疗方法是
这是必要的。最近的研究表明,神经元可以被招募,癫痫发作可以通过某种机制传播
这被称为电场耦合。我们的实验室已经证明,消除细胞外的电场
太空可以阻止神经的传播和招募。我们现在提议开发一种新的神经技术
不仅可以控制癫痫的传播,而且可以通过控制
胞外电场。采用体外电生理学和最新技术相结合的方法
在啮齿动物的神经成像、计算机建模和体内准备方面,我们将实施癫痫控制
系统研究其作用机制,有四个具体目的:1)防止过度兴奋的神经元同步化
神经组织,2)开发一种新的细胞外电压钳技术来控制体内癫痫发作,3)
确定细胞外电压钳系统控制癫痫发作的机制,4)确定
细胞外间隙对钳制效率的影响。目前的电反应控制疗法检测到癫痫发作
然后施加刺激。这项拟议的神经技术将阻止神经元之间的同步
在极低的电流幅度出现之前阻止癫痫的产生,从而提供了一种新的
治疗癫痫的治疗范例。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DOMINIQUE M DURAND其他文献
DOMINIQUE M DURAND的其他文献
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{{ truncateString('DOMINIQUE M DURAND', 18)}}的其他基金
Cellular and Neural Network Mechanism of Transcranial Electric Stimulation
经颅电刺激的细胞和神经网络机制
- 批准号:
10338804 - 财政年份:2021
- 资助金额:
$ 39.02万 - 项目类别:
Non-Invasive Oropharynx Appliance to Maintain Airway Patency
用于保持气道通畅的非侵入性口咽器具
- 批准号:
9906411 - 财政年份:2020
- 资助金额:
$ 39.02万 - 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
- 批准号:
10059285 - 财政年份:2019
- 资助金额:
$ 39.02万 - 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
- 批准号:
10517517 - 财政年份:2019
- 资助金额:
$ 39.02万 - 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
- 批准号:
10300055 - 财政年份:2019
- 资助金额:
$ 39.02万 - 项目类别:
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- 资助金额:
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