Seizure control by electric field control

通过电场控制进行咬合控制

基本信息

  • 批准号:
    10641916
  • 负责人:
  • 金额:
    $ 39.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-30 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

Abstract A seizure is an abnormal neural activity in the brain and the main characteristic of epilepsy. About one-third of the patients have seizures resistant to anti-epileptic medication and therefore, an alternative treatment is necessary. Recent studies show that neurons can be recruited and seizures can propagate by a mechanism known as electric field coupling. Our laboratory has shown that canceling the electric field in the extracellular space can prevent neural propagation and recruitment. We now propose to develop a novel neurotechnology that not only can control the propagation of seizures but prevent the seizure from being generated by controlling the extracellular electric field. With a combined methodology of in-vitro electrophysiology with state-of-the-art neural imaging, computer modeling and in-vivo preparations in rodents, we will implement the seizure control system and study its mechanism with four specific aims: 1) Prevent neuronal synchronization in hyperexcitable neural tissue, 2) Develop a novel technology of extracellular voltage clamp to control seizures in-vivo, 3) Determine the mechanisms of seizure control by an extracellular voltage clamp system, 4) Determine the role of the extracellular space in the clamping efficiency. Current electrical responsive control therapy detects a seizure and then applies stimulation. The proposed neurotechnology will prevent the synchronization between neurons to stop the generation of seizures before they arise at very low current amplitude thereby providing a novel therapeutic paradigm for treating epilepsy.
摘要

项目成果

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DOMINIQUE M DURAND其他文献

DOMINIQUE M DURAND的其他文献

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{{ truncateString('DOMINIQUE M DURAND', 18)}}的其他基金

Seizure control by electric field control
通过电场控制进行咬合控制
  • 批准号:
    10365510
  • 财政年份:
    2021
  • 资助金额:
    $ 39.02万
  • 项目类别:
Cellular and Neural Network Mechanism of Transcranial Electric Stimulation
经颅电刺激的细胞和神经网络机制
  • 批准号:
    10338804
  • 财政年份:
    2021
  • 资助金额:
    $ 39.02万
  • 项目类别:
Non-Invasive Oropharynx Appliance to Maintain Airway Patency
用于保持气道通畅的非侵入性口咽器具
  • 批准号:
    9906411
  • 财政年份:
    2020
  • 资助金额:
    $ 39.02万
  • 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
  • 批准号:
    10059285
  • 财政年份:
    2019
  • 资助金额:
    $ 39.02万
  • 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
  • 批准号:
    10517517
  • 财政年份:
    2019
  • 资助金额:
    $ 39.02万
  • 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
  • 批准号:
    10300055
  • 财政年份:
    2019
  • 资助金额:
    $ 39.02万
  • 项目类别:
Detection and Control of Epilepsy
癫痫的检测和控制
  • 批准号:
    8139519
  • 财政年份:
    2008
  • 资助金额:
    $ 39.02万
  • 项目类别:
Detection and Control of Epilepsy
癫痫的检测和控制
  • 批准号:
    8711567
  • 财政年份:
    2008
  • 资助金额:
    $ 39.02万
  • 项目类别:
Detection and Control of Epilepsy
癫痫的检测和控制
  • 批准号:
    9096236
  • 财政年份:
    2008
  • 资助金额:
    $ 39.02万
  • 项目类别:
Detection and Control of Epilepsy
癫痫的检测和控制
  • 批准号:
    8852197
  • 财政年份:
    2008
  • 资助金额:
    $ 39.02万
  • 项目类别:

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Synthesis and Biological Evaluation of Disubstituted Beta-Alanines as Antiepileptic Agents
双取代β-丙氨酸抗癫痫药的合成及生物学评价
  • 批准号:
    480799-2015
  • 财政年份:
    2015
  • 资助金额:
    $ 39.02万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's
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