Seizure control by electric field control
通过电场控制进行咬合控制
基本信息
- 批准号:10641916
- 负责人:
- 金额:$ 39.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAntiepileptic AgentsBrainCharacteristicsChronicClosure by clampCommunicationComputer ModelsComputer SimulationCouplingDataElectrodesElectrophysiology (science)EpilepsyExtracellular SpaceFocal SeizureFurosemideGenerationsGoalsHippocampusHumanImageIn VitroIronKainic AcidLaboratoriesMediatingMembraneMethodologyMethodsModelingNerve BlockNeuronsOsmolar ConcentrationPartial EpilepsiesPatientsPharmaceutical PreparationsPlayPreparationRecurrenceResearchResistanceRodentRoleSeizuresSystemTechniquesTechnologyTemporal Lobe EpilepsyTestingTissuesTravelTreatment Efficacyalternative treatmentdesignefficacy testingelectric fieldexperimental studyextracellularin vivoneuralneuroimagingneurotechnologynew technologynovelnovel strategiesnovel therapeuticsoptogeneticspreventrecruitvoltagevoltage clamp
项目摘要
Abstract
A seizure is an abnormal neural activity in the brain and the main characteristic of epilepsy. About one-third of
the patients have seizures resistant to anti-epileptic medication and therefore, an alternative treatment is
necessary. Recent studies show that neurons can be recruited and seizures can propagate by a mechanism
known as electric field coupling. Our laboratory has shown that canceling the electric field in the extracellular
space can prevent neural propagation and recruitment. We now propose to develop a novel neurotechnology
that not only can control the propagation of seizures but prevent the seizure from being generated by controlling
the extracellular electric field. With a combined methodology of in-vitro electrophysiology with state-of-the-art
neural imaging, computer modeling and in-vivo preparations in rodents, we will implement the seizure control
system and study its mechanism with four specific aims: 1) Prevent neuronal synchronization in hyperexcitable
neural tissue, 2) Develop a novel technology of extracellular voltage clamp to control seizures in-vivo, 3)
Determine the mechanisms of seizure control by an extracellular voltage clamp system, 4) Determine the role of
the extracellular space in the clamping efficiency. Current electrical responsive control therapy detects a seizure
and then applies stimulation. The proposed neurotechnology will prevent the synchronization between neurons
to stop the generation of seizures before they arise at very low current amplitude thereby providing a novel
therapeutic paradigm for treating epilepsy.
摘要
项目成果
期刊论文数量(0)
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DOMINIQUE M DURAND其他文献
DOMINIQUE M DURAND的其他文献
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{{ truncateString('DOMINIQUE M DURAND', 18)}}的其他基金
Cellular and Neural Network Mechanism of Transcranial Electric Stimulation
经颅电刺激的细胞和神经网络机制
- 批准号:
10338804 - 财政年份:2021
- 资助金额:
$ 39.02万 - 项目类别:
Non-Invasive Oropharynx Appliance to Maintain Airway Patency
用于保持气道通畅的非侵入性口咽器具
- 批准号:
9906411 - 财政年份:2020
- 资助金额:
$ 39.02万 - 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
- 批准号:
10059285 - 财政年份:2019
- 资助金额:
$ 39.02万 - 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
- 批准号:
10517517 - 财政年份:2019
- 资助金额:
$ 39.02万 - 项目类别:
Low-frequency stimulation of fiber tracts to control seizures
低频刺激纤维束以控制癫痫发作
- 批准号:
10300055 - 财政年份:2019
- 资助金额:
$ 39.02万 - 项目类别:
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