CORE--CELL SCIENCE
核心--细胞科学
基本信息
- 批准号:6590771
- 负责人:
- 金额:$ 17.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-04-01 至 2003-03-31
- 项目状态:已结题
- 来源:
- 关键词:apoptosis bioimaging /biomedical imaging biomedical facility confocal scanning microscopy cytology digital imaging electron microscopy fluorescence microscopy histology histopathology image processing immunocytochemistry in situ hybridization messenger RNA method development protein localization single cell analysis tissue /cell preparation tissue resource /registry
项目摘要
The Cell Science Core (CSC) is an integral part of the U54 Center,
providing services to its investigators and to the reproductive biology
researchers at the University of Virginia by funded by the NICHD RBS
Branch. The main goal of the CSC is to accomplish projects that rely on
tissue and cellular localization of antigenic molecules and messenger RNA
(mRNA), as well as morphologic analysis of pathologic tissue and cellular
changes. Dr. Kenneth Tung, a human and experimental pathologist with
expertise in reproduction and immunology, will continue to direct the CSC.
He will consult or collaborate on studies requiring preparation of high
quality tissue sections suitable for histology, immunohistology,
immunocytology, in situ hybridization and apoptotic cell detection, as
well as tissue and cellular localization of antigenic molecules and
interpretation of histopathology of animal tissues. He will work with Dr.
Mark Stoler, Co-director, a pathologist and an expert in situ
hybridization who will consult or collaborate on studies requiring mRNA
detection and quantitation. They will organize, prioritize, and quality-
control the work of Ms. Melissa Bevard, an experienced histologist and Ms.
Mary McCanna, an in situ hybridization technologist. When appropriate,
they will implement the transfer to investigators' laboratories techniques
through training of researchers, technicians, and monitoring of their
work. The CSC will also develop new technology in response to and in
anticipation of, research needs that will evolve in the U54. Examples
include: 1) double-antibody labeling technique and double-antibody/in situ
labeling technique, 2) confocal microscopy, 3) acquisition of reagents and
techniques for human translational and murine reproduction research.
External consultants have been recruited to serve the CSC to support this
endeavor. The Core will be adapted to meet the changing research needs of
the new U54 context. The P30-CSC unit has successfully provided quality
service to a growing number of reproductive biology researcher,
responsible for the completion of over 50 research projects and
acquisition of numerous NIH grant proposals.
细胞科学核心(CSC)是U 54中心的一个组成部分,
为研究人员和生殖生物学提供服务
弗吉尼亚大学的研究人员由NICHD RBS资助,
分支。CSC的主要目标是完成依赖于
抗原分子和信使RNA的组织和细胞定位
(mRNA)以及病理组织和细胞的形态学分析
变化Kenneth Tung博士是一位人类和实验病理学家,
在生殖和免疫学的专业知识,将继续指导CSC。
他将咨询或合作研究需要准备高
适用于组织学,免疫组织学,
免疫细胞学、原位杂交和凋亡细胞检测,
以及抗原分子的组织和细胞定位,
动物组织的组织病理学解释。他将与博士。
Mark Stallow,联合主任,病理学家和原位专家
杂交谁将咨询或合作的研究需要mRNA
检测和定量。他们会组织,优先,和质量-
控制梅利莎贝瓦德女士的工作,一位经验丰富的组织学家和女士。
原位杂交技术专家玛丽·麦坎纳。在适当的时候,
他们将把技术转移到研究人员的实验室,
通过培训研究人员、技术人员和监测其
工作CSC还将开发新技术,以应对
预测,研究需求将在U 54发展。示例
包括:1)双抗体标记技术和双抗体/原位
标记技术,2)共聚焦显微镜,3)试剂的获取,
用于人类翻译和小鼠生殖研究的技术。
已聘请外部顾问为CSC提供支持,
奋进。核心将进行调整,以满足不断变化的研究需求,
新U 54的背景。P30-CSC装置成功地提供了
为越来越多的生殖生物学研究人员提供服务,
负责完成50多个研究项目,
获得了大量的NIH拨款提案。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KENNETH S.K. TUNG其他文献
KENNETH S.K. TUNG的其他文献
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{{ truncateString('KENNETH S.K. TUNG', 18)}}的其他基金
Regulatory and effector T cells in SLE
SLE 中的调节性 T 细胞和效应性 T 细胞
- 批准号:
6663943 - 财政年份:2002
- 资助金额:
$ 17.42万 - 项目类别:
Antibody induced T cell mediated neonatal autoimmunity
抗体诱导 T 细胞介导的新生儿自身免疫
- 批准号:
6825714 - 财政年份:2002
- 资助金额:
$ 17.42万 - 项目类别:
Autoimmune Oophoritis: Consequences of Gamete Vaccines
自身免疫性卵巢炎:配子疫苗的后果
- 批准号:
6667129 - 财政年份:2002
- 资助金额:
$ 17.42万 - 项目类别:
Antibody induced T cell-mediated neonatal autoimmunity.
抗体诱导 T 细胞介导的新生儿自身免疫。
- 批准号:
8206614 - 财政年份:2002
- 资助金额:
$ 17.42万 - 项目类别:
Autoimmune Oophoritis: Consequences of Gamete Vaccines
自身免疫性卵巢炎:配子疫苗的后果
- 批准号:
6847457 - 财政年份:2002
- 资助金额:
$ 17.42万 - 项目类别:
Antibody induced T cell mediated neonatal autoimmunity
抗体诱导 T 细胞介导的新生儿自身免疫
- 批准号:
6983362 - 财政年份:2002
- 资助金额:
$ 17.42万 - 项目类别:
Antibody induced T cell mediated neonatal autoimmunity
抗体诱导 T 细胞介导的新生儿自身免疫
- 批准号:
6575358 - 财政年份:2002
- 资助金额:
$ 17.42万 - 项目类别:
Antibody-induced T cell-mediated neonatal autoimmunity
抗体诱导的 T 细胞介导的新生儿自身免疫
- 批准号:
6463504 - 财政年份:2002
- 资助金额:
$ 17.42万 - 项目类别: