IMMUNOPATHOGENESIS OF MYCOBACTERIUM & SIV COINFECTION IN MACAQUES

分枝杆菌的免疫发病机制

• 批准号: 6591336
• 负责人: Zheng W Chen
• 金额: $ 11.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6591336
• 关键词: AIDS; Mammalia; animal tissue; bacteria; communicable diseases; immunology; inflammation; lymphatic system; virus

Coinfection with HIV and Mycobacterium tuberculosis is associated with high rates of active tuberculosis and possibly an acceleration of the progression to clinical AIDS Elucidating the interplay of the immunopathogenic events that occur as a result of HIV/M tuberculosis coinfection is, therefore, of central importance for understanding the immune sequelae of this coinfection We have shown that macaques coinfected with SIV and Mycobacterium bovis Bacille Calmette-Guerin (BCG) develop a syndrome similar to AIDS-related tuberculosis Using this SIV/BCG coinfection model, we plan to study the immunopathogenesis of AIDS virus interactions with mycobacteria and the evolution of tuberculosis Publication Zou Z, Halloran M, Lee-Parritz D, Shen L, Simon M, Shen Y, Chen ZW In vivo effects of a bacterial superantigen on macaque TCR repertoires J Immunol, 160:5170-5180, 1998

与HIV和结核分枝杆菌共同感染与 有效的结核病率很高，并且可能加速 临床辅助的进展阐明了 HIV/M结核病导致的免疫致病事件 因此，共同感染对于理解 这种共同感染的免疫后遗症我们已经表明了猕猴 与SIV和分枝杆菌Calmille Calmette-Guerin共同发育 （BCG）发展一种类似于使用AIDS相关的结核病的综合征 这个SIV/BCG共感染模型，我们计划研究 艾滋病病毒与分枝杆菌相互作用的免疫发病发生 结核病出版的演变Zou Z，Halloran M， Lee-Parritz D，Shen L，Simon M，Shen Y，Chen ZW在体内效应 猕猴TCR曲目J Immunol上的细菌超抗原， 160：5170-5180，1998