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IMMUNOPATHOGENESIS OF MYCOBACTERIUM & SIV COINFECTION IN MACAQUES

IMMUNOPATHOGENESIS OF MYCOBACTERIUM & SIV COINFECTION IN MACAQUES
分枝杆菌的免疫发病机制
批准号：
6591336
负责人：
Zheng W Chen
金额：
$11.11万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-05-01 至 2003-04-30
来源：
https://reporter.nih.gov/project-details/6591336
关键词：
AIDS Mammalia animal tissue bacteria communicable diseases immunology inflammation lymphatic system virus

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英文摘要
Coinfection with HIV and Mycobacterium tuberculosis is associated with high rates of active tuberculosis and possibly an acceleration of the progression to clinical AIDS Elucidating the interplay of the immunopathogenic events that occur as a result of HIV/M tuberculosis coinfection is, therefore, of central importance for understanding the immune sequelae of this coinfection We have shown that macaques coinfected with SIV and Mycobacterium bovis Bacille Calmette-Guerin (BCG) develop a syndrome similar to AIDS-related tuberculosis Using this SIV/BCG coinfection model, we plan to study the immunopathogenesis of AIDS virus interactions with mycobacteria and the evolution of tuberculosis Publication Zou Z, Halloran M, Lee-Parritz D, Shen L, Simon M, Shen Y, Chen ZW In vivo effects of a bacterial superantigen on macaque TCR repertoires J Immunol, 160:5170-5180, 1998
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