NEUROBIOLOGY OF TROPANE ANALOG

项目11是一个协调的药物发现计划，涉及完整的 该中心所代表的分析能力范围。这是一个 继续许多实验室的合作努力，这些实验室是 以前被归类在一般核心结构之下。一种新型的托烷 由休·戴维斯博士的乙烯卡宾化学产生的类似物将是 对它们的神经化学效力、特异性和行为进行筛选 努力确定具有科学意义的化合物的行动 性质和/或治疗价值。将对化合物进行筛选，以确定其 单胺转运体及其受体的特异性和有效性 查尔德斯博士和班尼特博士的亲油性。选定的化合物将是 其特点是对DR患者的局部葡萄糖代谢有影响。 波里诺的实验室；她还将评估运动兴奋剂的效果 并确定它们的时间进程。史密斯医生会检查 部分托烷类化合物对胞外多巴胺和5-羟色胺的影响 通过微渗析研究的水平。自我管理研究 由罗伯茨博士进行的研究将检验 可用于碱性化合物分析的特定托烷类似物 关于精神刺激剂强化和AS的神经生物学问题 潜在的治疗靶点。

Project 11 is a coordinated drug discover program that involves the full range of analytical capabilities represented within the Center. It is a continuation of the collaborative efforts of many laboratories that were previously grouped under a general core structure. The novel tropane analogs produced by the vinylcarbenoid chemistry of Dr. Huw Davies will be screened for their neurochemical potency, specificity and behavioral actions in an effort to identify compounds with scientifically interesting properties and/or therapeutic value. Compounds will be screened for their specificity and efficacy at monoamine transporters and for their lipophilicity by Drs. Childers and Bennett. Selected compounds will be characterized for their effects on regional glucose metabolism in Dr. Porrino's laboratory; she will also assess the locomotor stimulant effects on these tropanes and determine their time course. Dr. Smith will examine the effects of selected tropanes on extracellular dopamine and serotonin levels through microdialysis studies. Self-administration studies conducted by Dr. Roberts will examine the relative reinforcing efficacy of specific tropane analogues that will be useful for the analysis of basic neurobiological questions concerning psychostimulant reinforcement and as potential therapeutic targets.