A Novel Animal Model of Cocaine Addiction

可卡因成瘾的新型动物模型

• 批准号: 6515858
• 负责人: David Charles Stephen Roberts
• 金额: $ 21.62万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515858
• 关键词: chordate locomotion; circadian rhythms; cocaine; disease /disorder model; drug addiction; eating; laboratory rat; model design /development; motivation; psychopharmacology; reinforcer; self medication

DESCRIPTION: Cocaine addiction in North America is a medical problem with profound social and financial cost. Approximately 2 million Americans use cocaine habitually, and those seeking treatment find it extraordinarily difficult to abstain and relapse rates are high. A medication that would help control the cravings for cocaine during the early stages of therapy would help retain patients in treatment programs. An animal model is essential for testing potentially therapeutic drugs and for evaluating the underlying neurobiology of drug abuse. This proposal will address two key features of the addictive process. The first is a progressive increase in the motivation to take cocaine and the second is the emergence of binge patterns of drug use. Cocaine self-administration in rats will be used to model these fundamental aspects of human drug taking. A novel procedure has been developed that permits continual access to cocaine (during discrete trials) throughout the 24 dark/light cycle. Different patterns of intake (either circadian or binge-like) are engendered depending on the dose and frequency of the trials. The overall objective of this proposal is to define the critical factors that model the addictive process. Specifically we will (1) define the parameters that affect the transition from controlled (circadian) intake to binge-like, dysregulated patterns of self-administration, (2) identify factors that lead to motivational changes across the cocaine addiction process (such as total intake, pattern to intake, and drug-free periods) and (3) characterize individual differences in the development of binge-like patterns of intake and an increased motivation to self-administer cocaine.

描述：北美可卡因成瘾是一个医学问题 深厚的社会和经济成本。大约200万美国人使用 可卡因习惯性，那些寻求治疗的人发现它非常 难以戒除，复发率很高。可以帮助的药物 在治疗的早期阶段控制可卡因的渴望将有助于 将患者保留在治疗计划中。动物模型对于测试至关重要 潜在的治疗药物，并评估 吸毒。该建议将介绍上瘾的两个关键特征 过程。首先是逐步增加可卡因的动机 第二个是药物使用的暴饮暴食模式的出现。可卡因 在大鼠中的自我管理将用于模拟这些基本方面 人类药物服用。已经开发了一种新的程序，可以连续 在整个24个黑暗/光周期中，访问可卡因（在离散试验期间）。 摄入的不同模式（昼夜节律）是产生的 取决于试验的剂量和频率。总体目标 该建议是定义模拟上瘾的关键因素 过程。具体来说，我们将（1）定义影响该参数的参数 从受控（昼夜节律）过渡到暴饮暴食，失调 自我管理的模式，（2）确定导致动机的因素 整个可卡因成瘾过程的变化（例如总摄入量，模式 摄入量和无药期）和（3）表征了个体差异 开发类似暴饮暴食的摄入量模式，并增加了动力 自我管理可卡因。