PSYCHOTHERAPY DEVELOPMENT RESEARCH CENTER

我们寻求更新我们的心理治疗研究中心，致力于开发，评估和完善药物滥用的心理治疗。组织的主题是心理治疗的发展和基于心理治疗研究的“技术模型”的实证检验（卡罗尔和Rounsaville，1990）。该中心的目标是促进创新药物滥用治疗的发展，从仅仅是“好主意”到能够广泛使用经验验证的治疗方法。这一过程需要在连续的、要求逐步提高的阶段进行研究。第1阶段包括试点测试、手册编写和培训计划开发;第2阶段包括对照疗效试验;第3阶段包括评价有效治疗在一般临床实践中的可推广性的研究。在中心活动的前4年中，我们成功地进行了6个最初提出的组成研究项目，完成了15个试点项目，并指导7名新的本地研究人员开发了他们的第一个外部支持的行为治疗研究项目。我们还通过咨询耶鲁大学以外的14个资助项目的发展，为8个主要的多地点行为和/或药物治疗疗效试验提供手册指导培训，开发培训包，以促进更广泛地使用有效的药物滥用治疗，并提供有关心理治疗研究的方法和战略问题的咨询国家组织，作为心理治疗研究的国家资源。在更新期间，研究将继续围绕一个核心设施和7个单独的研究组成部分的阶段模型组织。核心工作人员将为中心项目提供科学监督、管理和技术援助，并为其他研究中心的研究人员和临床医生提供咨询和技术转让服务。第一阶段的三个项目将开发新的方法：对吸毒父亲的父母关系干预，双重诊断患者的动机访谈（MET）和对吸毒者的情感调节疗法。第二阶段的三个项目将评估以下方面的疗效：十二步促进，以加强双硫仑对可卡因依赖，改善法庭推荐的Maritime用户的参与和结果，以及提高抗逆转录病毒药物的依从性。第三阶段的一个项目将评估一般情况下的低成本应急管理。

We seek to renew our psychotherapy research center dedicated to the development, evaluation and refinement of psychotherapies for drug abuse. The organizing theme is psychotherapy development and empirical testing based on the "technology model" of psychotherapy research (Carroll and Rounsaville, 1990). The Center's goal is to catalyze the development of innovative drug abuse treatments from the point where they are merely "good ideas" to one where they are capable of widespread use of empirically validated treatments. The process requires research at sequential, progressively demanding stages. Stage 1 consists of pilot testing, manual writing and training program development: Stage II consists of controlled efficacy trials; Stage III consists of studies to evaluate generalizability of efficacious treatments to general clinical practice. During the first 4 years of Center activities, we have successfully conducted the 6 originally proposed component research projects, completed 15 pilot projects and guide 7 new local investigators to develop their first externally supported research projects on behavioral treatment. We have also served as a national resource for psychotherapy research by consulting on development of 14 funded projects outside Yale, providing manual guided training for 8 major multisite behavioral and/or pharmacotherapy efficacy trials, developing training packages to foster more widespread use of efficacious substance abuse treatments and providing consultation on methodological and strategic issues related to psychotherapy research to national organization. During renewal period, research will continue to be organized around the stage model with a CORE facility and 7 individual research components. Core staff will provide scientific oversight, administration and technical assistance to Center projects and also provide consultation and technology transfer services to investigators and clinicians at other sites. Three Stage I projects will develop new approaches: A Relational Parent Intervention for Drug Abusing Fathers, Motivational Interviewing (MET) for Dual Diagnosis Patients and Affect Regulation Therapy for Cocaine Abusers. Three Stage II projects will evaluate efficacy of the following: Twelve Step Facilitation to Enhance Disulfiram for Cocaine Dependence, Improving Engagement & Outcome for Court-Referred Marijuana Users, and Improving Adherence to Anti-retroviral Medication. One Stage III project will evaluate Low-Cost Contingency Management for General Settings.