Evaluation of Vestibular Function in Meniere's Disease

梅尼埃病前庭功能的评估

• 批准号: 6480035
• 负责人: Lloyd Brooks Minor
• 金额: $ 29.31万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6480035
• 关键词: Meniere's disease; auditory stimulus; disease /disorder etiology; ear disorder chemotherapy; eye movements; gentamicins; head movements; human subject; labyrinthectomy; otocyst /otolith; pathologic process; patient oriented research; physiology; sensorineural hearing loss; tympanum; vertigo; vestibular apparatus; vestibuloocular reflex

DESCRIPTION:(provided by applicant) The objective of the proposed research is to understand the pathophysiology of the vestibular disturbances in Meniere's disease and how to treat them. The specific effects (both qualitative and quantitative) on vestibular function of both Meniere's disease itself and of intratympanic gentamicin used to alleviate vertigo are unknown and will be determined in the proposed research. The research strategy is to analyze the vestibuloocular reflex (VOR) in three dimensions from responses to stimuli that activate the semicircular canals or the otoliths. Vestibular function will also be evaluated from measurements of the subjective visual vertical and from vestibular-evoked myogenic potentials. The angular VOR evoked by high-frequency, high-acceleration head thrusts will be studied in order to determine the effects of Meniere's disease and of intratympanic gentamicin on the function of individual semicircular canals. The translational VOR in these patients will be evaluated from the responses to rapid, lateral translations of the head. Through comparisons with findings in subjects with normal vestibular function and those with known surgical unilateral vestibular destruction (UVD), these studies will provide a new understanding of the effects of Meniere's disease itself, and the effects of treatment with gentamicin, on individual vestibular end organs. Recovery of the VOR after intratympanic gentamicin and after surgical UVD will be assessed through analyses of the trajectories of eye velocity. The corrective eye movements that reduce the gaze errors that occur as a consequence of diminished vestibular function in the responses to high acceleration angular and translational head movements will also be analyzed. The information derived from this research will have practical import on which vestibular tests are most useful in Meniere's disease, and on deciding when and with what to treat patients with Meniere's disease.

描述：（申请人提供） 拟议研究的目的是了解 Meniere病的前庭障碍以及如何治疗它们。这 对前庭功能的特定效果（定性和定量） Meniere氏病本身以及用于减轻 眩晕是未知的，将在拟议的研究中确定。这 研究策略是在三个中分析前庭反射（VOR） 从反应到激活半圆形管或刺激的尺寸 耳石。前庭功能也将从测量中进行评估 主观视觉垂直和来自前庭诱发的肌源性潜力。 高频，高加速头推力引起的角度将 进行研究以确定Meniere病和 甲状腺内庆大霉素对个体半圆形管的功能。这 这些患者的翻译VOR将从对 头部快速，横向翻译。通过与发现的比较 具有正常前庭功能的受试者和已知手术的受试者 单侧前庭破坏（UVD），这些研究将提供新的 了解Meniere病本身的影响，以及 用庆大霉素，单个前庭末端器官进行治疗。 内胰蛋白酶蛋白和手术UVD后的VOR恢复 可以通过分析眼速度的轨迹进行评估。这 纠正眼动动作减少了作为一个作为一个作为 前庭功能降低的后果在对高的响应中 加速度角和翻译头运动也将进行分析。 从这项研究中得出的信息将具有实用的进口 前庭测试在Meniere氏病以及决定何时和 用什么治疗Meniere病的患者。