Evaluation of Vestibular Function in Meniere's Disease

描述：（申请人提供） 这项研究的目的是了解 梅尼埃病的前庭功能障碍及其治疗的 对前庭功能的特定影响（定性和定量） 梅尼埃病本身和鼓室内庆大霉素用于缓解 眩晕是未知的，将在拟议的研究中确定。的 研究策略是分析前庭眼反射（VOR）在三个 从激活半规管的刺激反应的尺寸，或 耳石前庭功能也将通过测量 主观视觉垂直和前庭诱发肌源性电位。 由高频率、高加速度头部推力引起的角VOR将 研究以确定梅尼埃病和 鼓室内注射庆大霉素对个体半规管功能的影响。的 这些患者的VOR翻译将根据对以下各项的反应进行评估： 头部的快速横向平移。通过与调查结果的比较， 具有正常前庭功能的受试者和已知具有外科手术的受试者 单侧前庭破坏（UVD），这些研究将提供一个新的 了解梅尼埃病本身的影响，以及 庆大霉素治疗，对个体前庭终末器官。 鼓室内庆大霉素注射和UVD手术后VOR的恢复将 通过分析眼动速度的轨迹来评估。的 矫正眼球运动，减少发生的凝视错误， 前庭功能减弱的后果，在高反应， 还将分析加速度角和平移头运动。 从这项研究中得到的信息将具有实际意义， 前庭试验在梅尼埃病中是最有用的， 治疗梅尼埃病的方法

DESCRIPTION:(provided by applicant) The objective of the proposed research is to understand the pathophysiology of the vestibular disturbances in Meniere's disease and how to treat them. The specific effects (both qualitative and quantitative) on vestibular function of both Meniere's disease itself and of intratympanic gentamicin used to alleviate vertigo are unknown and will be determined in the proposed research. The research strategy is to analyze the vestibuloocular reflex (VOR) in three dimensions from responses to stimuli that activate the semicircular canals or the otoliths. Vestibular function will also be evaluated from measurements of the subjective visual vertical and from vestibular-evoked myogenic potentials. The angular VOR evoked by high-frequency, high-acceleration head thrusts will be studied in order to determine the effects of Meniere's disease and of intratympanic gentamicin on the function of individual semicircular canals. The translational VOR in these patients will be evaluated from the responses to rapid, lateral translations of the head. Through comparisons with findings in subjects with normal vestibular function and those with known surgical unilateral vestibular destruction (UVD), these studies will provide a new understanding of the effects of Meniere's disease itself, and the effects of treatment with gentamicin, on individual vestibular end organs. Recovery of the VOR after intratympanic gentamicin and after surgical UVD will be assessed through analyses of the trajectories of eye velocity. The corrective eye movements that reduce the gaze errors that occur as a consequence of diminished vestibular function in the responses to high acceleration angular and translational head movements will also be analyzed. The information derived from this research will have practical import on which vestibular tests are most useful in Meniere's disease, and on deciding when and with what to treat patients with Meniere's disease.