PHYSIOLOGY OF VESTIBULAR COMPENSATION

描述：（改编自研究者摘要） 建议的研究是了解更多的机制负责 前庭眼反射（VOR）的不对称性 病变研究策略是分析系统的响应，通过 旋转和平移刺激的眼动研究，单单位 记录、电流极化和控制系统建模。 在前庭损伤（管堵塞）之前和之后研究反应 或包皮环切术）。这项研究是在松鼠猴和 龙猫 这些研究将包括在发射前对VOR角进行三维分析。 以及前庭损伤后。垂直和扭转的动力学 将审查答复。兴奋性和抑制性的贡献 信号在确定角VOR的对准后， 将定义前庭病变。VOR角坐标系 将在选定的根管堵塞之前和之后进行测量。 角VOR信号处理的神经机制将是 研究了不同的生理群所携带的信号 将定义前庭神经传入。中枢前庭神经系统的反应 参与角VOR控制的神经元将被研究， 频率和加速度旋转刺激已经被证明可以引起 单侧前庭损伤后反射的不对称性。 将研究耳间平移诱发的线性VOR（侧向LVOR） 单侧睾丸切除术前后。耳石传入神经的反应 测量的线性加速度范围，以及它们在控制 将定义横向LVOR。旋转和旋转的相互作用 将研究平移VOR。 本研究对于阐明细胞凋亡的基本机制具有重要意义。 前庭眼信号处理和用于改进诊断和治疗 前庭紊乱的症状

DESCRIPTION: (Adapted from the Investigator's Abstract) The objective of the proposed research is to learn more about the mechanisms responsible for asymmetries in the vestibuloocular reflex (VOR) after unilateral vestibular lesions. The research strategy is to analyze responses of the system through eye-movement studies with rotational and translational stimuli, single-unit recordings, galvanic labyrinthine polarizations, and control systems modeling. Responses are investigated before and after vestibular lesions (canal plugging or labyrinthectomy). The research is conducted in squirrel monkeys and in chinchillas. The studies will involve a three-dimensional analysis of the angular VOR before and after vestibular lesions. The dynamics of the vertical and torsional responses will be examined. The contributions of excitatory and inhibitory signals in determining the alignment of the angular VOR after unilateral vestibular lesions will be defined. The coordinate frame of the angular VOR will be measured before and after plugging of selected canals. The neural mechanisms underlying signal processing in the angular VOR will be investigated. The signals carried by different physiological groups of vestibular-nerve afferents will be defined. The responses of central vestibular neurons involved in control of the angular VOR will be studied for higher frequency and acceleration rotational stimuli that have been shown to evoke asymmetries in the reflex after unilateral vestibular lesions. The linear VOR evoked by interaural translations (lateral LVOR) will be studied before and after unilateral labyrinthectomy. The responses of otolith afferents to a range of linear accelerations measured, and their role in the control of the lateral LVOR will be defined. The interactions of rotational and translational VORs will be investigated. This research has importance for defining the basic mechanisms of vestibuloocular signal processing and for improving the diagnosis and treatment of vestibular disorders in humans.