Spectral Pattern ERG for Diagnosis of Glaucoma

光谱模式 ERG 用于诊断青光眼

• 批准号: 6672663
• 负责人: HARRY G SPERLING
• 金额: $ 14.86万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6672663
• 关键词: clinical research; diagnosis design /evaluation; electrodes; electrophysiology; electroretinography; eye disorder diagnosis; glaucoma; glaucoma test; human subject; intraocular pressure; optic disk; retinal ganglion; visual fields; visual fixation

DESCRIPTION (provided by applicant): Through a series of research and design studies, the Principal Investigator has arrived at a technique and apparatus concept for a diagnostic test for glaucoma which promises to confirm functional loss at a stage of the disease before there are reliable signs of visual field loss, a high priority aim of research in the glaucoma area. Preliminary data on populations of normal subjects, glaucoma suspects and confirmed glaucoma patients show no overlap in test scores between the normal subjects and the confirmed glaucoma patients. Statistically significant differences were also found between the mean scores of normal and of suspects. and between mean scores of suspects and of confirmed cases. It is proposed here to do an enlarged and improved study, which will meet more exacting criteria by having the selection and documentation of subjects performed by a glaucoma specialist, unavailable in the preliminary studies, and by keeping the testing personnel masked from the diagnosis. The diagnostic technique utilizes a new approach that involves opposing achromatic and chromatic stimulation in the pattern ERG, which provides a null point measurement which is less variable than the usual measurement. The preliminary data show very clearly that the null point shifts significantly in glaucoma. It shifts in a way which provides evidence that luminance ganglion cells are lost before color-opponent ganglion cells in glaucoma, which meshes with anatomical evidence. The proposed approach also has the advantage of fully automatic testing with the patient required only to maintain fixation, obviating the need for the patient to make frequently difficult subjective judgments. It also shows promise, which will be studied, of very rapid assessment of visual field loss and of treatment effectiveness, utilizing new signal processing procedures.

描述(申请人提供)：通过一系列的研究和设计研究，首席调查员已经形成了青光眼诊断测试的技术和仪器概念，承诺在出现可靠的视野丧失迹象之前确认疾病阶段的功能丧失，这是青光眼领域研究的优先目标。对正常受试者、青光眼可疑患者和确诊青光眼患者人群的初步数据显示，正常受试者和确诊青光眼患者之间的测试分数没有重叠。正常组和疑似组的平均分也有显著差异。嫌疑人和确诊病例的平均数之间的差距。这里建议进行一项扩大和改进的研究，这将满足更严格的标准，由青光眼专家进行受试者的选择和记录，这在初步研究中是无法获得的，并使测试人员对诊断隐蔽。该诊断技术利用了一种新的方法，该方法涉及在模式ERG中反对无色和有色刺激，该方法提供了比通常的测量变量更小的零点测量。初步数据非常清楚地显示，青光眼患者的零点显著移位。它的变化方式提供了证据，证明在青光眼中，亮度神经节细胞在与颜色相反的神经节细胞之前丢失，这与解剖学证据相吻合。建议的方法还具有全自动测试的优点，患者只需要保持固定，而不需要患者经常做出困难的主观判断。它还显示了利用新的信号处理程序非常快速地评估视野损失和治疗效果的前景，这一点将被研究。