Extraocular muscle aging: Functional and genomic changes

眼外肌老化:功能和基因组变化

基本信息

  • 批准号:
    6620398
  • 负责人:
  • 金额:
    $ 15.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-02-05 至 2005-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: (Applicant's Abstract) The incapacitating consequences of skeletal muscle aging are even more obvious when a muscle group is preferentially affected. The extraocular muscles (EOMs) present a combination of abundant mitochondria, high calcium content, and almost constant activity, and are preferentially targeted by conditions that have been linked to oxidative stress like chronic progressive external ophthalmoplegia and related disorders. This project intends to demonstrate that the EOMs are particularly vulnerable to the effects of age, and may be used as a model for the study of skeletal muscle aging. In the analysis of aging mechanisms, the study of the exceptional cell or tissue response may prove to be of considerable value in understanding the norm. Uncovering the mechanisms for the apparent susceptibility of the EOMs to aging should contribute to knowledge of both skeletal muscle aging mechanisms and palliative or preventive interventions. The overall hypothesis is that the high mitochondrial content and activity rates of EOMs lead to greater generation of reactive oxygen species (ROS), and render these muscles exceptionally susceptible to age-related loss of function. Specific Aim 1 will detennine how age alters the generation of ROS in rat EOMs. The hypothesis that EOMs produce ROS at a higher rate throughout life will be tested in rats of three ages (6-, 18- and 30mo) with biochemical indices of oxidative stress. Specific Aim 2 will analyze the effect of age on contractile properties and calcium handling capacity of rat EOMs. The hypothesis that the function of EOM deteriorates with age because of loss of calcium handling capacity will be tested by studying the kinetics of free cytosolic calcium during contractile activity in single muscle fibers using microfluorometry, and the contractile properties of whole EOMs and selected skeletal muscles in vitro. Specific Aim 3 will evaluate the effect of age on rat EOM gene transcription. The hypothesis that age alters gene expression in EOMs to a greater extent than in other skeletal muscles will be tested using cDNA microarray technology. The results from this project will establish whether life-long oxidative stress is an important deleterious influence on the EOMs, and may prove this particular muscle group is a viable model for the study of skeletal muscle aging.
描述:(申请人摘要)骨骼的失能后果

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Francisco H Andrade其他文献

Time management in the busy professional environment: take that first step.
繁忙的职业环境中的时间管理:迈出第一步。
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    29.4
  • 作者:
    Francisco H Andrade
  • 通讯作者:
    Francisco H Andrade

Francisco H Andrade的其他文献

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{{ truncateString('Francisco H Andrade', 18)}}的其他基金

Impact of EOM specific myosin loss on extraocular muscle structure and function
EOM 特异性肌球蛋白损失对眼外肌结构和功能的影响
  • 批准号:
    8680609
  • 财政年份:
    2014
  • 资助金额:
    $ 15.1万
  • 项目类别:
Impact of EOM specific myosin loss on extraocular muscle structure and function
EOM 特异性肌球蛋白损失对眼外肌结构和功能的影响
  • 批准号:
    8822875
  • 财政年份:
    2014
  • 资助金额:
    $ 15.1万
  • 项目类别:
Clock genes, environmental challenges and cardiopulmonary disease
时钟基因、环境挑战和心肺疾病
  • 批准号:
    7940849
  • 财政年份:
    2009
  • 资助金额:
    $ 15.1万
  • 项目类别:
Respiratory Muscle Weakness in Chronic Inflammation
慢性炎症导致的呼吸肌无力
  • 批准号:
    8446919
  • 财政年份:
    2009
  • 资助金额:
    $ 15.1万
  • 项目类别:
Determinants of extraocular muscle function
眼外肌功能的决定因素
  • 批准号:
    7847306
  • 财政年份:
    2009
  • 资助金额:
    $ 15.1万
  • 项目类别:
Clock genes, environmental challenges and cardiopulmonary disease
时钟基因、环境挑战和心肺疾病
  • 批准号:
    7837306
  • 财政年份:
    2009
  • 资助金额:
    $ 15.1万
  • 项目类别:
Research Training in Muscle Biology of Cardiopulmonary Disease
心肺疾病肌肉生物学研究培训
  • 批准号:
    8244994
  • 财政年份:
    2008
  • 资助金额:
    $ 15.1万
  • 项目类别:
Aging of the Intrinsic Laryngeal Muscles
喉内肌的老化
  • 批准号:
    7026818
  • 财政年份:
    2004
  • 资助金额:
    $ 15.1万
  • 项目类别:
Aging of the Intrinsic Laryngeal Muscles
喉内肌的老化
  • 批准号:
    6931406
  • 财政年份:
    2004
  • 资助金额:
    $ 15.1万
  • 项目类别:
Extraocular muscle aging: Functional and genomic changes
眼外肌老化:功能和基因组变化
  • 批准号:
    6708858
  • 财政年份:
    2002
  • 资助金额:
    $ 15.1万
  • 项目类别:

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