Massage to Enhance Well-Being: HIV+ Dominican Children

按摩增强健康：艾滋病毒多米尼加儿童

基本信息

批准号：
6661951
负责人：
Gail Shor-Posner
金额：
$ 18.62万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-15 至 2005-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Worldwide, more than 1.3 million children are living with HIV/AIDS, which is becoming the leading infectious cause of cognitive and developmental delays, especially in infants and children with marked immune dysfunction. There is compelling evidence that massage therapy may have the potential to enhance immune status and alter the course of HIV disease. In support of this concept, increased immune cytotoxic capacity and improvement in HIV disease progression markers have been demonstrated following massage therapy in HIV-1 seropositive adolescents and adults, even in the absence of antiretroviral treatments. Although the ability of massage therapy to enhance immune function in HIV-1 infected children has not yet been investigated, increased weight gain, decreased stress behavior, and more optimal cognitive and motor development have been reported following massage treatment in studies with premature newborns. The intent of this proposed developmental research grant is to examine the efficacy of massage therapy, an affordable and potentially beneficial complementary/alternative treatment, to promote health and enhance well being in HIV-1 seropositive children in the Dominican Republic, a developing country ravaged by HIV/AIDS. The number of pediatric HIV/AIDS cases has been rapidly rising in the Dominican Republic, and antiretroviral regimens are not yet readily available to slow disease progression. We propose to randomize 54 HIV-1 infected Dominican children aged 3-7 years, to receive massage therapy or standard care/friendly visits, twice weekly for 12 weeks. Preliminary data will be gathered to assess acceptance, safety, and compliance to massage therapy, and examine whether massage treatment will improve immune function, developmental performance and behavioral function. We hypothesize that massage therapy will be a valid, safe, and sustainable form of care. If proven effective, this may have widespread application with a focus on training of family/care givers to administer the massage treatment. Insights obtained from this project will be used to develop an application for future studies to determine the effectiveness of massage therapy, its impact on the immune system, and potential mechanisms involved in preserving health status over time in HIV-1 seropositive children.

描述（由申请人提供）：全球，有130万儿童患有艾滋病毒/艾滋病，这成为认知和发展延迟的主要传染病，尤其是在免疫功能障碍明显的婴儿和儿童中。有令人信服的证据表明，按摩疗法可能有可能增强免疫状态并改变HIV疾病的病程。为了支持这一概念，在HIV-1血清阳性青少年和成年人的按摩治疗后，即使没有抗逆转录病毒治疗，已经证明了艾滋病毒疾病进展标志物的免疫细胞毒性能力和艾滋病毒疾病进展标志物的改善。尽管尚未研究按摩疗法在HIV-1感染儿童中增强免疫功能的能力，但在对早产新生儿的研究中按摩治疗后，体重增加，压力降低，压力下降和更最佳的认知和运动发育均得到了据报道。这项拟议的发展研究补助金的目的是检查按摩疗法的功效，一种负担得起的互补/替代疗法，以促进健康并增强多米尼加共和国的HIV-1血清阳性儿童的健康，这是艾滋病毒/艾滋病遭受的发展中国家。多米尼加共和国的小儿艾滋病毒/艾滋病病例的数量迅速增加，抗逆转录病毒方案尚不容易缓慢疾病进展。我们建议将3-7岁的54个HIV-1感染的多米尼加儿童随机分配，以接受按摩疗法或标准护理/友好访问，每周两次，持续12周。将收集初步数据以评估按摩治疗的接受，安全性和遵守情况，并检查按摩治疗是否会改善免疫功能，发育绩效和行为功能。我们假设按摩疗法将是一种有效，安全和可持续的护理形式。如果被证明有效，这可能具有广泛的应用，重点是培训家庭/护理人员来管理按摩治疗。从该项目获得的见解将用于开发未来研究的应用程序，以确定按摩疗法的有效性，其对免疫系统的影响以及在HIV-1血清阳性儿童中保留健康状况的潜在机制。