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OPTIMIZING HIV/TB MANAGEMENT IN THE HAART ERA

HAART 时代优化 HIV/TB 管理

基本信息

批准号：
7497217
负责人：
Gail Shor-Posner
金额：
$ 9.57万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-24 至 2009-05-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7497217
关键词：
AIDS Dementia Complex AIDS clinical trial group AIDS prevention AIDS/HIV problem Academic degree Accounting Achievement Acquired Immunodeficiency Syndrome Adam11 gene Address Adherence Admission activity Adolescent Adult Affect Africa Africa South of the Sahara Age-Years Alabama Alcohols Ambulatory Care Facilities American Americas Anti-Retroviral Agents Antitubercular Agents Appendix Area Argentina Arts Attention Authorization documentation Award Awareness Bacteria Behavior Therapy Behavioral Behavioral Research Behavioral Sciences Bioethics Brain Brazil Breast Feeding CCL22 gene CD4 Lymphocyte Count Calmette-Guerin Bacillus Caribbean natives Caribbean region Caring Cause of Death Centers for Disease Control and Prevention (U.S.)Child Child Care Childbirth Childhood Cities Clinic Clinical Clinical Nurse Specialists Clinical Research Clinical Sciences Clinical Services Clinical Trials Cognitive Collaborations Colombia Combined Modality Therapy Commit Communicable Diseases Communities Complement Complementary therapies Complex Comprehensive Health Care Country Dentists Depth Detection Deterioration Developed Countries Developing Countries Development Diagnosis Diagnostic Discipline of obstetrics Disclosure Discrimination Disease Disease Management Disease Progression Disease Resistance Doctor of Philosophy Dominican Dominican Republic Drug Addiction Drug Interactions Drug abuse Drug resistance Drug user Economics Education Educational process of instructing Educational workshop Effectiveness Effectiveness of Interventions Environment Epidemic Epidemiology Ethics Evaluation Exhibits Face Faculty Female Adolescents Florida Fostering Foundations Functional disorder Funding Future Gender Genetic Genotype Genus Mycobacterium Goals Government Grant Guyana HIV HIV Infections HIV Seropositivity HIV-1 HIV-1 vaccine Haiti Head Health Health Personnel Health Policy Health Professional Health Services Health Services Accessibility Health education Healthcare Heterosexuals High Prevalence Highly Active Antiretroviral Therapy Home environment Honduras Hospitalization Hospitals Human Human Resources Human Rights Human Virology Immune Immune system Immunologic Monitoring Immunology Improve Access Incidence Indigenous Individual Infant Infection Information and Communication Theory Institutes Institution Instruction International International AIDS Internet Intervention Investigation Jamaica Joints Journals Knowledge Laboratories Laboratory Research Laboratory Technicians Lantana Last Name Latin America Leadership Letters Life Lipodystrophy Local Government Malaria Maryland Massage Medical Medical center Medicine Mental Health Services Mental disorders Methods Microbiology Minority Modeling Molecular Biology Mothers Names National Center for Complementary and Alternative Medicine National Institute of Allergy and Infectious Disease National Institute of Child Health and Human Development National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Nebraska Needs Assessment Neurocognitive Neurosecretory Systems New York Newsletter Numbers Nurses Nutritional Nutritionist Observational Study Operations Research Orphan Outcome Palliative Care Pan American Health Organization Parenting behavior Patients Pattern Pediatric Hospitals Pediatrics Perception Perinatal Personal Satisfaction Persons Peru Pharmaceutical Preparations Pharmacists Pharmacologic Substance Physicians Placebo Control Policy Maker Population Population Growth Positioning Attribute Postdoctoral Fellow Postpartum Period Poverty Predisposition Pregnant Women Prevalence Prevention Prevention Research Prevention education Prevention intervention Prevention program Prevention strategy Primary Health Care Principal Investigator Printing Procedures Process Programmed Learning Provider Psychiatry Psychologist Psychology, Other Public Health Public Health Education Public Health Schools Public Policy Publications Quality of life RNA Interference Race Range Rate Readiness Recreational Drugs Reporting Research Research Activity Research Ethics Research Infrastructure Research Methodology Research Project Grants Research Training Resistance Resources Risk Risk Factors Risk Reduction Role Rotation Ruthenium Ben Scientist Secondary Prevention Sentinel Services Sex Behavior Signal Transduction Site Social Aspects of Cancer Social Impacts Source Stigmata Stigmatization Stress Structure Substance abuse problem Support System Suriname Technology Terminal Disease Testing Today Toxic effect Training Training Activity Training Programs Training Support Training in Biomedical and Behavioral Research Tuberculosis USAID Uganda United Nations United States United States National Institutes of Health Universities University Hospitals Vaccination Vaccines Vertical Disease Transmission Vision Vulnerable Populations West Indies Woman Wood material Work World Bank Writing abstracting antiretroviral therapy biopsychosocial burden of illness care burden chlorambucil/dactinomycin/methotrexate protocol cohort coping cost day design disease natural history disorder control disorder prevention experience feeding group counseling health care service utilization health economics high risk behavior high risk sexual behavior immune function improved interest international center intervention program medical schools men men who have sex with men migration mortality multidisciplinary mycobacterial pandemic disease pediatric AIDS prenatal programs psychologic psychological stressor psychosocial research study response size skills social stigma sound stress management success symposium therapeutic vaccine tool transmission process treatment program tuberculosis drugs tuberculosis treatment vaccine development

项目摘要

Approximately 93% of the global HIV infections occur in the developing world, with Latin America accounting for 1.5 million cases and the Caribbean, which has the highest HIV prevalence rate outside of sub-Saharan Africa, for 440,00 more, indicating the critical need for an international effort to control HIV spread in these countries. Through the auspices of the Miami Fogarty AITRP and Pediatric programs, 175 government- endorsed scholars have received instruction in AIDS/TB prevention and treatment, returning home (92+% return rate) to guide their countries with initiatives and strategies to reduce the burden of disease. With the advent of highly active antiretroviral therapy (HAART), possibilities of HIV-1 suppression and control have emerged. In response to increasing access to HAART in Latin America and the Caribbean our objectives for the next five years are designed to promote independent and sustainable scientific capacity that will enable Fogarty scholars to assist their countries in conducting wide-scale programs to: 1) Promote optimal treatment and care of children and adults living with HIV/AIDS and those co-infected with HIVFI'B; 2) Enhance adherence for HIV/TB treatment, and reduce the potential for drug resistance; 3) Determine obstacles in access to care, including the impact of stigma on utilization of health services; 4) Identify continued high-risk behaviors and establish appropriate interventions to reduce risk of transmission, and improve quality of life in the era of HAART; and 5) Evaluate the economic and social impact of prevention and treatment interventions. The establishment of effective scientific infrastructures, and long-standing partnerships between Miami and host- country institutions will permit the challenges facing our target countries (Brazil, Colombia, Dominican Republic, Guyana, Jamaica, Peru) to be addressed. These objectives will be implemented in the context of ethical procedures and will include attention to the economic and social impact of research operations. We propose to integrate the research expertise of our in-country Fogarty scholars with biomedical and behavioral research training, according to the specific needs of the host countries. Research training will be conducted in Miami and the host countries, to facilitate independent research capacity and sustainable interventions, to ultimately quell the tide of the epidemic. PERFORMANCESITE(S) (organization, city, state) Division of Disease Prevention Department of Psychiatry and Behavioral Sciences University of Miami School of Medicine KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Shor-Posner, Gall, PhD University of Miami-School of Medicine Ashkin, David, MD A.G. Holley State Tuberculosis Hospital Goodman, Kenneth, PhD University of Miami-School of Medicine McCoy, Clyde, PhD University of Miami-School of Medicine Miguez-Burbano, Maria Jose, PhD, MD University of Miami-School of Medicine Mitchell, Charles, MD University of Miami-School of Medicine Scott, Gwendolyn, MD University of Miami-School of Medicine Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. [] Yes [] No PHS 398 (Rev. 05/01 Page 2 shown below. Role on Project Principal Investigator Director, TB Director, Ethics Director, Research Co-PI Co-PI Director, Pediatrics Form Page 2 PrincipInavl estigator/PrDoigreracmt(oLarst, first, middle):Shor-Posner,G. The name of the principal investigatodprogram director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Face Page .................................................................................................................................................. Description,

全球大约93%的艾滋病毒感染发生在发展中国家，拉丁美洲占艾滋病毒感染率最高的加勒比地区（除撒哈拉以南非洲地区外）非洲，440，000多人，表明迫切需要国际努力控制艾滋病毒在这些国家的传播。国家通过迈阿密福格蒂AITRP和儿科项目的赞助，175个政府- 获得认可的学者接受了艾滋病/结核病预防和治疗方面的指导，返回家园（92%+ 回报率），以指导其国家采取减少疾病负担的举措和战略。与随着高效抗逆转录病毒疗法（HAART）的出现，抑制和控制HIV-1的可能性已经涌现为了应对拉丁美洲和加勒比地区越来越多的人获得高效抗逆转录病毒治疗，我们的目标是：未来五年的目标是促进独立和可持续的科学能力，福格蒂学者协助他们的国家进行大规模的计划，以：1）促进最佳治疗（b）对感染艾滋病毒/艾滋病的儿童和成年人以及同时感染艾滋病毒/乙型肝炎的儿童和成年人的治疗和护理; 用于艾滋病毒/结核病治疗，并减少耐药性的可能性; 3）确定获得护理的障碍，包括污名对卫生服务利用的影响; 4）识别持续的高危行为，建立适当的干预措施，以减少传播风险，并提高生活质量， HAART; 5）评估预防和治疗干预措施的经济和社会影响。的建立有效的科学基础设施，以及迈阿密和主办方之间的长期合作伙伴关系- 国家机构将允许我们的目标国家（巴西、哥伦比亚、多米尼加共和国、圭亚那、牙买加、秘鲁）。这些目标将在以下背景下实施：道德程序，并将包括对研究活动的经济和社会影响的关注。我们建议将我们国内福格蒂学者的研究专长与生物医学和行为学相结合，研究培训，根据东道国的具体需要。研究培训将在迈阿密和东道国，以促进独立的研究能力和可持续的干预措施，最终平息疫情。地点（组织、城市、州）疾病预防处精神病学和行为科学系迈阿密大学医学院关键人员。参见说明。根据需要使用续页，以下列格式提供所需信息：从首席研究员开始。按字母顺序列出所有其他关键人员，姓在前。名称机构 Shor-Posner，Gall，PhD迈阿密大学医学院 Ashkin，大卫，医学博士霍利州立结核病医院 Goodman，Kenneth，博士迈阿密大学医学院麦考伊，克莱德，博士迈阿密大学医学院 Miguez-Burbano，Maria Jose，PhD，MD迈阿密大学医学院 Mitchell，Charles，MD迈阿密大学医学院 Scott，Gwendolyn，MD迈阿密大学医学院披露许可声明。仅适用于SBIR/STTR。参见说明。[]是[]否 PHS 398（2001年5月修订版，第2页如下所示. 在项目中的作用主要研究者主任，结核病伦理司司长研究部主任共同主持共同主持儿科主任表格第2页主要研究者/首席研究员（最大，第一，中间）：Shor-Posner，G. 必须在每一打印页和每一续页的顶部提供主要赞助商和项目负责人的姓名。研究资助目录首页...... 产品描述：