TISSUE STRESS VARIABILITY AND STRENGTH IN VERTEBRAL BONE

椎骨的组织应力变化和强度

• 批准号: 6561112
• 负责人: YENER N YENI
• 金额: $ 20.1万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-10 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6561112
• 关键词: X ray; biological polymorphism; bone; bone density; bone fracture; bone imaging /visualization /scanning; computed axial tomography; gender difference; human tissue; mechanical pressure; physical property; postmortem; racial /ethnic difference; skeletal stress; spine; statistics /biometry; substantia spongiosa; vertebrae

DESCRIPTION (provided by applicant): A great percentage of the elderly population is at the risk of a vertebral fracture due to osteoporosis. Fractures of thoracic 12 and lumbar 1 constitute the majority of these vertebral fractures. External factors, such as loading, being aside, bone quality is the major determinant of a fracture. The measure of bone quality that is relevant to fracture is bone strength. However, current measures of bone quality, such as bone mineral density, are only surrogates of bone strength and have variable diagnostic success. New technologies with potentially high diagnostic value that are under development make use of the observation that bone stiffness and strength are highly correlated, i. e., how much load the bone can carry before fracture is related to how flexible the bone is under a given load. How these two apparent properties are related through bone's microstructural organization and to what extent bone stiffness is related to bone strength are very fundamental questions of bone biology. We believe that the close relationship between the apparent strength and apparent stiffness of cancellous bone is a result of an adaptation where tissue (trabeculae) stress magnitude and variability is controlled through microstructural organization such that the average and the scatter of the tissue stresses are correlated. This project will determine the relationships between bone microstructure, tissue stress distributions and bone apparent properties at a tissue and organ level for T4-L5 vertebrae from human spines using microcomputed tomography, large-scale finite element analysis and mechanical testing. The results of this project will reveal: (i) whether greater levels of damaging stresses are generated in the tissue from T12-L1 junction independent of external factors, (ii) whether the association between tissue stresses and bone apparent properties is sensitive to the choice of within-patient and between-patient samples, (iii) microstructural features of bone that give rise to damaging forms of stresses in the tissue, and (iv) whether vertebral bone strength at the organ level can be predicted by stiffness measurements using the concepts introduced for cancellous bone tissue. The long-term goal of this research is to enhance our ability to diagnose and develop strategies for prevention of bone disease and failure through a better understanding of the stress-regulated structure of vertebral bone.

描述（由申请人提供）：很大比例的老年人因骨质疏松而有椎体骨折的风险。这些椎体骨折主要发生在胸椎12和腰椎1。除了载荷等外部因素外，骨质量是骨折的主要决定因素。与骨折有关的骨质量的度量是骨强度。然而，目前的骨质量测量，如骨矿物质密度，只是骨强度的替代品，诊断成功率也不确定。正在开发的具有潜在高诊断价值的新技术利用了骨骼刚度和强度高度相关的观察结果，即骨骼在骨折前可以承受的载荷与骨骼在给定载荷下的柔韧性有关。这两种明显的特性是如何通过骨的微观结构组织联系起来的，以及骨刚度与骨强度之间的关系在多大程度上是骨生物学的基本问题。我们认为松质骨的表观强度和表观刚度之间的密切关系是一种适应的结果，其中组织（小梁）应力大小和变异性是通过微观结构组织控制的，这样组织应力的平均值和散射是相关的。本项目将通过显微计算机断层扫描、大规模有限元分析和力学测试，确定人体T4-L5椎骨在组织和器官水平上的骨微观结构、组织应力分布和骨表观特性之间的关系。该项目的结果将揭示：(i) T12-L1连接是否独立于外部因素在组织中产生更大水平的损伤应力，（ii）组织应力和骨表观特性之间的关联是否对患者内和患者间样本的选择敏感，（iii）骨骼的微结构特征导致组织中损伤形式的应力，（iv）是否可以使用引入的松质骨组织的概念通过刚度测量来预测器官水平的椎体骨强度。这项研究的长期目标是通过更好地了解椎体骨的应力调节结构来提高我们诊断和制定预防骨疾病和骨衰竭策略的能力。