"Interoperative" Quick Parathyroid Hormone Assay

“互操作”快速甲状旁腺激素测定

• 批准号: 6543067
• 负责人: Richard T Chang
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6543067
• 关键词: AIDS; AIDS therapy; HIV infections; Toxoplasma; angiography; antiAIDS agent; antiprotozoal agents; blood tests; diagnosis design /evaluation; diagnosis procedure safety; diagnostic tests; drug administration routes; drug adverse effect; encephalitis; endocrine surgery; human subject; human therapy evaluation; naphthoquinones; nervous system infection; opportunistic infections; parathyroid gland; parathyroid hormones; patient oriented research; pyrimethamine; rapid diagnosis; toxoplasmosis; veins

Parathyroid venous sampling remains the most precise localization technique for patients with failed parathyroid surgery but it requires considerable experience on the part of the angiographer as well as prolonged catheter manipulation to sample the multiple small veins draining the neck and mediastinum. Knowledge of the presence of parathyroid hormone (PTH) gradients during the procedure would enable the angiographer to focus on a specific area, perhaps obtaining more detailed samples and to shorten the procedure when significant gradients occur in the early samples. This protocol will not increase the accuracy of sampling but will shorten the procedure, reduce radiation exposure to the patient and to the interventional radiologist and allow more precise localization by more focused sampling. The success of another protocol 94-DK-0195 has decreased the number of patients who need parathyroid venous sampling so our original estimates of the frequency of the study are no longer valid. At the current time, it would be difficult to accrue enough patients to complete this study in a timely fashion. The test has proven effective in the few OR patients accrued and we no longer consider it to be investigational. It is now used in routine patient care when needed. No new subjects were enrolled this year. We have terminated this protocol.

甲状旁腺静脉采样仍然是甲状旁腺手术失败患者最精确的定位技术，但它需要血管造影师的丰富经验以及长时间的导管操作，以采集颈部和纵隔引流的多个小静脉。在手术过程中了解甲状旁腺激素（PTH）梯度的存在将使血管造影师能够专注于特定区域，可能获得更详细的样本，并在早期样本中出现显著梯度时缩短手术时间。该方案不会增加采样的准确性，但会缩短程序，减少对患者和介入放射科医生的辐射暴露，并通过更集中的采样实现更精确的定位。另一项方案94-DK-0195的成功减少了需要甲状旁腺静脉采样的患者数量，因此我们对研究频率的原始估计不再有效。目前，难以招募足够的患者及时完成本研究。该测试已被证明在少数OR患者中有效，我们不再认为它是研究性的。它现在用于需要时的常规患者护理。今年未招募新受试者。我们已经终止了这个协议。