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Bioactivity Of Neuropeptides

Bioactivity Of Neuropeptides
神经肽的生物活性
批准号：
6673283
负责人：
LAWRENCE H LAZARUS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6673283
关键词：
endogenous opioid neuropeptides peptide analog pharmacokinetics

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英文摘要
Summary of Work: The pharmacological and physiological activity of recently developed opioid analogues were determined in mice. The bioactivity profile paralled that of the in vitro pharmacological data and reflected the receptor binding affinity (see previous projects for details). Some synthetic analogues which exhibited agonism were weaker than the control substances (deltorphin for delta or morphine for mu receptors); however, some were substantially better (2- to 25-fold) than morphine in generating analgesia using standard testing procedures. In fact, these compounds are under patent application in Japan and disclosure at this time would jepardize that process.
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MOLECULAR DYNAMICS CONFORMATION OF OPIOID PEPTIDES
MOLECULAR DYNAMICS CONFORMATION OF OPIOID PEPTIDES
Bioactivity Of Neuropeptides
Molecular Dynamics Conformation Of Opioid Peptides
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