STEREOCONTROLLED IMINE-ALLYLSILANE CYCLIZATIONS

描述：(主要研究人员摘要)新技术的发展 提高药物合成效率的方法 是生物医学研究的中心目标。新反应的阐明 支持选择性有机转换的类型仍然是这一点的基础 努力吧。在这项拨款申请中提出的研究涉及 多用途分子检测新方法的发现与应用 环扎术。 在上一个供资期间，首席调查员和他的 同事们已经证明了各种立体化学上不同的杂环 可以通过实验上简单的方法以极好的选择性制备 化学反应的类别。预计这种新反应的使用 类型，以及它的机械相关变体，将允许快速 获得重要类别的合成中间体用于药理 研究。这项建议概述了我们为实现这一目标而制定的近期计划。 目的和详细说明在合成精选化合物中的具体应用 生物活性分子。

DESCRIPTION: (Principal Investigator's Abstract) The development of new processes by which the efficiency of pharmaceutical synthesis can be improved is a central goal of biomedical research. The elucidation of novel reaction types that enable selective organic transformations remains fundamental to this endeavor. The research proposed within this grant application is concerned with the discovery and application of versatile new methods for molecular annulation. During the preceding funding period, the Principal Investigator and his coworkers have shown that a variety of stereochemically diverse heterocycles can be prepared with excellent selectivity by an experimentally straightforward class of chemical reactions. It is expected that the use of this new reaction type, as well as mechanistically related variants of it, will permit rapid access to important classes of synthetic intermediates for pharmacological research. This proposal outlines our immediate plans for the pursuit of this objective and details specific applications to the synthesis of selected bioactive molecules.