CORE -- DIAGNOSIS AND SYMPTOM ASSESSMENT

核心——诊断和症状评估

• 批准号: 6812813
• 负责人: JOSEPH VENTURA
• 金额: $ 6.1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-19 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6812813
• 关键词: biomedical facility; diagnosis design /evaluation; diagnosis procedure safety; diagnosis quality /standard; human subject; interview; mental disorder diagnosis; neuropsychological tests; schizophrenia; sign /symptom; training; videotape /videodisc

The primary goal of the Diagnosis and Symptom Assessment Core (DSAC) is to provide specialized diagnostic and psychiatric symptom assessment training and quality assurance procedures to projects and cores within the Translational Center for Neurocognition and Emotion in Schizophrenia. The DSAC will train interviewers who conduct screening and evaluation of patients across three phases of illness in the Prodromal Research Project, the Aftercare Research Program, and the Chronic Schizophrenia Recruitment and Assessment Core. The DSAC will be responsible for establishing and maintaining high levels of interrater reliability, preventing rater drift, and improving the reliability and validity of Center instruments. To accomplish these goals, the DSAC will: 1) maintain well standardized, comprehensive and reliable training and quality assurance methods for prodromal signs assessment, diagnosis of DSM-IV disorders, psychiatric symptom assessment, and measurement of insight, 2) maintain reliability standards and criteria for certification of diagnosticians, diagnostic interviewers, and symptom raters who use assessment instruments such as the SCID-I, SCID-II, SIPS, SOPS, BPRS, SANS, SAPS, and SUMD-R, 3) ensure high levels of interrater reliability for diagnosticians who will be conducting training and quality assurance procedures, and 4) expand the DSAC training videotape library to include updated structured interviews for generating diagnoses and symptom rating scales. Phase I of the training program requires that diagnostic interviewers and symptom assessors rate a minimum of six training videotapes and have interrater reliability calculated using the accompanying "Gold Standard" consensus diagnoses and ratings. For the SIPS, SOPS, BPRS, SANS, SAPS, and SUMD-R, we will require that the trainee obtain a minimum Intraclass Correlation Coefficient (ICC) of .80 across all items and all six training videotapes. These requirements must be met or the trainee will attend remediation sessions before "graduating" to Phase II of training, which requires conducting 4 "live" assessments for each measure. The DSAC will also formally evaluate interviewer style, e.g., ability to probe for symptoms. All interviewers will enter a quality assurance program aimed at preventing rater "drift." Each interviewer will be required to demonstrate, as evaluated with kappa and ICC statistics, high levels of interrater reliability by continuing to conduct "live" interviews and co-rating assessments conducted by a senior Center diagnostician. The DSAC will collaborate with other Cores for Clinical Samples and Center Projects around research questions such as instrument development, method development, and improving interrater reliability.

诊断和症状评估核心(DSAC)的主要目标是为精神分裂症神经认知和情感翻译中心内的项目和核心提供专门的诊断和精神症状评估培训和质量保证程序。DSAC将培训面试者，他们在前驱研究项目、后续护理研究计划和慢性精神分裂症招募和评估核心中对患者进行三个阶段的筛查和评估。DSAC将负责建立和维护高水平的评委间可靠性，防止评委漂移，并提高中心工具的可靠性和有效性。为了实现这些目标，DSAC将：1)保持良好标准化、全面和可靠的培训和质量保证方法，用于先兆症状评估、DSM-IV疾病的诊断、精神症状评估和自知力测量；2)维护可靠性标准和标准，用于认证使用SCID-I、SCID-II、SIPS、SOPS、BPR、SANS、SAPS和SUMD-R等评估工具的诊断师、诊断面试员和症状评分员；3)确保将进行培训和质量保证程序的诊断人员在审查员之间的高度可靠性；以及4)扩大DSAC培训录像带资料库，包括最新的结构化面谈，以生成诊断和质量保证程序 症状评定量表。培训计划的第一阶段要求诊断面试者和症状评估员对至少六盘培训录像带进行评分，并使用附带的“黄金标准”共识诊断和评级来计算评价者之间的可靠性。对于SIPS、SOPS、BPR、SANS、SAPS和SUMD-R，我们将要求学员获得所有项目和所有六盘培训录像带的最小组内相关系数(ICC)为.80。必须满足这些要求，否则受训者将在“毕业”到第二阶段培训之前参加补救会议，该阶段要求对每项措施进行4次“现场”评估。DSAC还将正式评估面试者的风格，例如探查症状的能力。所有面试官都将参加一个旨在防止评分员“漂移”的质量保证计划。每个面试者将被要求展示，如Kappa和ICC所评估的那样 通过继续进行“现场”访谈和由一名高级中心诊断师进行的联合评级评估，评审员之间的高水平可信度。DSAC将与临床样本和中心项目的其他核心围绕研究问题进行合作，如仪器开发、方法开发和提高评价者之间的可靠性。