SCOR IN PEDIATRIC CARDIOVASCULAR DISEASE

小儿心血管疾病中的 SCOR

• 批准号: 6640638
• 负责人: RONALD M LAUER
• 金额: $ 95.09万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6640638
• 关键词: congenital heart disorder; developmental genetics; histogenesis

(Adapted from the Applicant's Abstract) This SCOR entitled "Genes Involved in Cardiac Development" consists of six projects and one Core Laboratory. The themes of this SCOR relate to the identification, characterization and function of genes that relate to cardiac development. These projects and the core laboratory are integrated in their efforts and directed by investigators who have appointments in the Departments of Anatomy and Cell Biology, Biochemistry, Biological Sciences, Pediatrics (Cardiology and Genetics), Physiology and Biophysics and Preventive Medicine and Environmental Health. The SCOR program does not try to address all of the basic and clinical issues related to congenital heart disease. The major focus and rationale for the SCOR Program is as follows: There exists a genetic susceptibility to atrial septal, ventricular septal and AV canal defects. The genes that are involved in the formation of these septal areas of the heart will be identified from temporal and spatial studies of rodent embryos and will become candidates for further investigation in this SCOR. Project 1, a human study, will recruit and examine probands with these three cardiac malformations and their family members. The DNA from these subjects will be used to carry out linkage and association studies of candidate genetic regions using STRP markers characterized in individual as well as pooled DNA samples. Project 2 along with the In Situ Core Laboratory will identify genes that are spatially and/or temporally regulated during heart development. Project 3 will evaluate the role of differentially expressed genes in cardiac morphogenesis that relate to the three defects as well as other congenital malformations. Project 4 will study the role of dystroglycan which is expressed throughout the embryonic heart during development. Project 5 will focus on the spatial-temporal regulation of coronary vasculogenesis and angiogenesis which is necessary for myocardial and septal development. Project 6 will develop vectors to allow investigation of spatial and temporal expression of genes involved in septal and other morphologic areas during early cardiac development. In Situ Core Laboratory will localize temporal and spatial patterns of expressions of selected clones for Projects 3, 4, 5, and 6. These efforts have great potential to identify genes that are risk factors for the development of frequently occurring cardiac birth defects and thus have the additional potential of developing preventive measures.

（根据申请人摘要改编）这个名为“心脏发育基因”的SCOR由六个项目和一个核心实验室组成。 该SCOR的主题涉及与心脏发育相关的基因的鉴定、表征和功能。这些项目和核心实验室整合在他们的努力，并由谁拥有在解剖学和细胞生物学，生物化学，生物科学，儿科（心脏病学和遗传学），生理学和生物物理学和预防医学和环境卫生部门任命的研究人员指导。SCOR计划并不试图解决与先天性心脏病相关的所有基础和临床问题。 SCOR项目的主要重点和基本原理如下：房间隔、室间隔和AV管缺损存在遗传易感性。 参与心脏这些隔膜区域形成的基因将从啮齿动物胚胎的时间和空间研究中确定，并将成为本SCOR进一步研究的候选者。 项目1是一项人类研究，将招募和检查这三种心脏畸形的先证者及其家庭成员。 这些受试者的DNA将用于使用个体和合并DNA样本中表征的STRP标记进行候选遗传区域的连锁和关联研究。 项目2与原位核心实验室一起沿着将鉴定在心脏发育过程中受到空间和/或时间调节的基因。 项目3将评估差异表达基因在心脏形态发生中的作用，这些基因与这三种缺陷以及其他先天性畸形有关。项目4将研究肌营养不良蛋白聚糖在整个胚胎心脏发育过程中的作用。 项目5将重点关注心肌和间隔发育所必需的冠状动脉血管发生和血管生成的时空调节。项目6将开发载体，以研究心脏发育早期间隔和其他形态学区域相关基因的时空表达。 原位核心实验室将定位项目3、4、5和6所选克隆表达的时间和空间模式。 这些努力有很大的潜力，以确定基因的危险因素，经常发生的心脏出生缺陷的发展，从而有额外的潜力，制定预防措施。

项目成果

Mechanical, cellular, and molecular factors interact to modulate circulating endothelial cell progenitors.

机械、细胞和分子因素相互作用来调节循环内皮细胞祖细胞。

• DOI: 10.1152/ajpheart.00431.2003
• 发表时间: 2004
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Wang,Chunlin;Jiao,Chunhua;Hanlon,HeatherD;Zheng,Wei;Tomanek,RobertJ;Schatteman,GinaC
• 通讯作者: Schatteman,GinaC

Chordin affects pronephros development in Xenopus embryos by anteriorizing presomitic mesoderm.

脊索蛋白通过前体中胚层影响非洲爪蟾胚胎中前肾的发育。

• DOI: 10.1002/dvdy.21014
• 发表时间: 2007
• 期刊: Developmental dynamics : an official publication of the American Association of Anatomists
• 作者: Mitchell,Tracy;Jones,ElizabethA;Weeks,DanielL;Sheets,MichaelD
• 通讯作者: Sheets,MichaelD

Is a shorter atrioventricular septal length an intermediate phenotype in the spectrum of nonsyndromic atrioventricular septal defects?

• DOI: 10.1016/j.echo.2012.03.011
• 发表时间: 2012-07
• 期刊: JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
• 影响因子: 6.5
• 作者: Patel, Sonali S.;Mahoney, Larry T.;Burns, Trudy L.
• 通讯作者: Burns, Trudy L.

Role of growth factors in coronary morphogenesis.

生长因子在冠状动脉形态发生中的作用。

• 发表时间: 2002
• 期刊: Texas Heart Institute journal
• 影响因子: 0.9
• 作者: Tomanek,RobertJ;Zheng,Wei
• 通讯作者: Zheng,Wei

Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells.

• DOI: 10.1152/ajpheart.00410.2004
• 发表时间: 2004-12
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Wei Zheng;Lance P. Christensen;R. Tomanek