EPIDEMIOLOGY OF CAROTID ARTERY ATHEROSCLEROSIS IN YOUTH

青年颈动脉粥样硬化的流行病学

• 批准号: 2233167
• 负责人: RONALD M LAUER
• 金额: $ 41.22万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2233167
• 关键词: EPIDEMIOLOGY; CAROTID; ARTERY; ATHEROSCLEROSIS; YOUTH

DESCRIPTION: (Adapted from Investigator's Abstract) The atherosclerotic process begins in childhood and advances through adult life when occlusive vascular disease results in coronary heart disease, stroke and peripheral vascular disease. Although risk factors have been established in adult populations, risk factors when measured in childhood have not been directly related to morbidity and mortality from occlusive atherosclerotic disease. The ultrasonographic measurement of carotid artery intimal-medial thickness (IMT) in adults is related not only to the risk for stroke but also to the severity of atherosclerotic disease in the coronary arteries. In 1970, a population of school age children and adolescents was first examined in Muscatine, Iowa, and since then has been followed to examine the predictive value of childhood risk factor levels for cardiovascular disease. A sample of this longitudinal cohort, with risk factors measured at least twice during childhood and once during adult life, is available for study. It is representative of the initial population, which presently ranges in age from 31 to 40 years, and lives in the Muscatine area. The investigators note that this cohort provides an opportunity to examine the relationship of risk factors measured in childhood to IMT in early adulthood and to examine familial factors which may be related to increased IMT. In this application, the investigators describe a study to examine the following: 1) the relationship of body mass index (BMI), blood pressure, total cholesterol, and smoking behaviors measured in childhood to IMT measured in early adulthood; 2) the relationship of risk factors (BMI, blood pressure, total cholesterol, LDL-C, HDL-C, Apo A1, Apo B, Lp(a), Apo E genotypes, glucose insulin and smoking) to IMT in young adults; 3) the relationship of risk factor 'load' from childhood to adult life to IMT; 4) the relationship of IMT in young adults to familial mortality in first- and second-degree relatives due to vascular disease; and 5) the degree of familial aggregation of IMT in young adults and their parents. The investigators believe this study will provide a view of the significance of IMT in young adults not only in its relationship to risk factors in childhood and young adulthood but also to familial factors that may be responsible for accelerated atherosclerosis.

描述：(改编自《调查者摘要》)动脉粥样硬化 这一过程始于童年，并在以下情况下进入成年 闭塞性血管疾病导致冠心病、中风和 外周血管疾病。尽管风险因素一直是 在成人人群中确立，风险因素在 儿童时期与以下疾病的发病率和死亡率没有直接关系 闭塞性动脉粥样硬化性疾病。超声心动图的测量 成人颈动脉内中膜厚度与颈动脉内膜中层厚度无关 不仅与中风的风险有关，而且与动脉粥样硬化的严重程度有关 冠状动脉疾病。1970年，一群学龄儿童 儿童和青少年首先在爱荷华州的马斯卡廷接受检查，并 从那时起，人们一直在跟踪检查童年的预测价值 心血管疾病的危险因素水平。一个这样的例子 纵向队列，风险因素至少测量两次 童年和成年时各一次，可供学习。它是 代表初始人口，目前年龄各不相同 从31岁到40岁，住在马斯卡廷地区。调查人员 请注意，这群人提供了一个检查关系的机会 从儿童期测量的危险因素到成年早期的IMT，以及 检查可能与IMT增加有关的家族性因素。 在本申请中，调查人员描述了一项研究，以检查 1)体重指数(BMI)、血压、 总胆固醇和儿童吸烟行为测量到IMT 在成年早期测量；2)危险因素(BMI， 血压、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白A1、载脂蛋白B、脂蛋白(A)、 载脂蛋白E基因分型、葡萄糖、胰岛素和吸烟)与IMT的关系； 3)儿童时期危险因素“负荷”与成年生活的关系 4)青壮年IMT与家族死亡率的关系 因血管疾病的一级和二级亲属；以及5) 青少年及其父母IMT的家族聚集度。 调查人员相信，这项研究将为我们提供一个关于 IMT在年轻人中的意义不仅在于其与风险的关系 儿童期和成年期的因素，但也有家庭因素 这可能是加速动脉粥样硬化的原因。