Development of orthopaedic implants based on an improved model of the mineral - collagen interface in bone

基于骨骼中矿物-胶原界面的改进模型开发骨科植入物

• 批准号: 2277811
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2277811
• 关键词: Development; orthopaedic; implants; based; improved

The projects aim is to produce alternating collagen-mineral layers to model in vivo calcified tissue. The deposition of each layer can be carefully controlled using pulsed electrophoretic deposition with a variety of parameters available, including applied voltage, pulse time and pulse width. It is important to mimic natural bone formation on both nano and microscopic scales due to the enhanced cell migration into the material and cell proliferation which enables its use in bone tissue engineering. The analysis of structures produced will use a variety of techniques including nuclear magnetic resonance imaging.

该项目的目的是产生交替的胶原矿物质层，以模拟体内钙化组织。每层的沉积可以使用具有各种可用参数（包括施加的电压、脉冲时间和脉冲宽度）的脉冲电泳沉积来仔细控制。在纳米和微观尺度上模拟天然骨形成是重要的，因为增强的细胞迁移到材料中和细胞增殖使得其能够用于骨组织工程。对产生的结构的分析将使用各种技术，包括核磁共振成像。