Development of orthopaedic implants based on an improved model of the mineral - collagen interface in bone

该项目的目标是生产交替的胶原蛋白-矿物层，以在体内模拟钙化组织。每一层的沉积都可以使用脉冲电泳沉积来仔细控制，其中包括施加电压、脉冲时间和脉冲宽度等各种可用参数。在纳米和微观尺度上模拟自然骨的形成是非常重要的，因为它可以促进细胞向材料中的迁移和细胞增殖，从而使其能够在骨组织工程中使用。对产生的结构的分析将使用包括核磁共振成像在内的各种技术。

The projects aim is to produce alternating collagen-mineral layers to model in vivo calcified tissue. The deposition of each layer can be carefully controlled using pulsed electrophoretic deposition with a variety of parameters available, including applied voltage, pulse time and pulse width. It is important to mimic natural bone formation on both nano and microscopic scales due to the enhanced cell migration into the material and cell proliferation which enables its use in bone tissue engineering. The analysis of structures produced will use a variety of techniques including nuclear magnetic resonance imaging.