Analysis of Advanced Motion Kinetics and Kinematics, Correlated with Proteomic Approach to Biological Assessment of the Joint

与关节生物学评估的蛋白质组学方法相关的高级运动动力学和运动学分析

• 批准号: 2278425
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2278425
• 关键词: Analysis; Advanced; Motion; Kinetics; Kinematics

This project runs at the interface of biomedical engineering, cell biology and clinical orthopaedic surgery. It is a directly translatable project that allows the student to develop skills applicable to a variety of disciplines and also experience with patient interaction. The student will analyse the gait of patients using advanced motion capture technology, before and after knee replacement surgery and quantify knee range of motion, muscle strength, stability and gait kinematics. The student would primarily be assessing and quantifying the biomechanics of the individual patient and how the extent of disease and muscle weakness affects their movement and ability to undertake activities of daily living. The student would look specifically at the frontal plane kinematics and change in joint line and tibial inclination of the knee when the surgery is done with using personalised kinematic alignment techniques and mechanical alignment techniques. The biological milieu of the joint is important to gait and function. A proteomics approach to analysis of synovial fluid obtained at the knee replacement surgery will endeavour to correlate, for the first time, the biological and biomechanical objective measurements of patients with osteoarthritis of the knee, to personalise and improve their treatment and rehabilitation. The proteomics aspect of the study will further our understanding of how the biological environment affects function and builds on work at the Stoller Biomarker Discovery Centre, University of Manchester.The project partners Medacta are at the cutting edge of biomedical engineering for patient benefit, and have developed inhouse 3D printing of bespoke personalised instruments and implants from 3DCT planning of surgery. The student will interact with the international bioengineering team at Medacta and learn the processes of invention to testing, licensing and commercialisation. Medacta has offered the successful student a paid internship of 6 months duration at the end of their project in addition to the placements during the studentship.

该项目在生物医学工程，细胞生物学和临床骨科手术的界面上运行。这是一个可直接翻译的项目，允许学生发展适用于各种学科的技能，并与患者互动的经验。学生将使用先进的运动捕捉技术分析患者的步态，在膝关节置换手术前后，量化膝关节的运动范围，肌肉力量，稳定性和步态运动学。学生将主要评估和量化个体患者的生物力学，以及疾病和肌肉无力的程度如何影响他们的运动和进行日常生活活动的能力。当使用个性化运动学对线技术和机械对线技术完成手术时，学生将特别关注额状面运动学以及关节线和膝关节胫骨倾斜度的变化。关节的生物环境对步态和功能很重要。蛋白质组学方法分析膝关节置换手术中获得的滑液，将首次努力关联膝关节骨关节炎患者的生物学和生物力学客观测量值，以个性化并改善其治疗和康复。该研究的蛋白质组学方面将进一步加深我们对生物环境如何影响功能的理解，并建立在曼彻斯特大学Stoller生物标志物发现中心的工作基础上。项目合作伙伴Medacta处于生物医学工程的前沿，为患者提供福利，并开发了定制个性化器械和植入物的内部3D打印，来自3DCT手术规划。学生将与Medacta的国际生物工程团队互动，学习发明到测试，许可和商业化的过程。Medacta在项目结束时为成功的学生提供了为期6个月的带薪实习，以及学生期间的实习机会。