Continuous Measurement of Breathlessness

连续测量呼吸困难

• 批准号: 6585727
• 负责人: JOHN C BAIRD
• 金额: $ 41.28万
• 依托单位: PSYCHOLOGICAL APPLICATIONS, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-10 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585727
• 关键词: asthma; biomedical equipment development; bronchodilators; cardiopulmonary disease; chronic obstructive pulmonary disease; clinical research; computer assisted diagnosis; computer system design /evaluation; diagnosis design /evaluation; dyspneas; exercise; psychometrics; pulmonary respiration; respiratory insufficiency /failure

DESCRIPTION (provided by applicant): The objective of this research is to evaluate a computer-assisted, continuous method for measuring breathlessness during exercise. The method represents a new approach to obtain subjective ratings from patients exercising on a cycle ergometer or treadmill. Whereas the "gold standard" Borg scale for measuring breathlessness is employed in over one million patients per year, it is limited by the fact that each estimate occurs at a discrete point in time cued or signaled by the health professional, rather than when the patient senses a change in symptom intensity. Moreover, if the patient cannot verbalize a response (e.g., while breathing through a mouthpiece), the rating must be indicated on the scale by finger pointing. During exercise this can lead to uncertainty on the part of the clinician as to exactly where the patient is pointing. The continuous method for obtaining patient-initiated ratings is unencumbered by these limitations, while also providing a direct measure of the absolute threshold and peak of breathlessness. The software to obtain such ratings has been shown to be reliable, valid, and easy to use. Thus far, the method has been successfully applied in patients with chronic obstructive pulmonary disease. The goal of Phase II is to evaluate the new methodology with a wider sample of adult patients afflicted with asthma, interstitial lung disease, respiratory muscle weakness, and pulmonary vascular disease, as well as with a group of children with asthma. Tests will also be conducted to investigate the responsiveness of the continuous method to track the effects of bronchodilator therapy and respiratory load. PROPOSED COMMERCIAL APPLICATION. The commercial goal is to replace the discrete scale with a computer-administered continuous method for measuring breathlessness during exercise. The product marketed in Phase III will be a computer software package that will be purchased by physicians, clinics and hospitals throughout the world.

描述(由申请人提供)：这项研究的目的是评估一种计算机辅助的、连续的方法来测量运动中的呼吸困难。该方法代表了一种新的方法，可以从在自行车功率机或跑步机上锻炼的患者那里获得主观评分。尽管每年有100多万名患者使用博格量表来测量呼吸困难，但它受到以下事实的限制：每次评估都发生在卫生专业人员提示或发出信号的离散时间点，而不是当患者感觉到症状强度的变化时。此外，如果患者不能用言语表达反应(例如，当通过口罩呼吸时)，必须用手指在秤上指示评级。在锻炼期间，这可能会导致临床医生不确定患者到底指的是哪里。获得患者自主评分的连续方法不受这些限制的阻碍，同时还提供了对呼吸困难的绝对阈值和峰值的直接测量。获得此类评级的软件已被证明是可靠、有效和易于使用的。到目前为止，该方法已成功应用于慢性阻塞性肺疾病患者。第二阶段的目标是在更广泛的患有哮喘、间质性肺疾病、呼吸肌无力和肺血管疾病的成人患者以及一组哮喘儿童患者中评估新方法。还将进行测试，以调查跟踪支气管扩张剂治疗和呼吸负荷效果的连续方法的响应性。建议的商业应用。商业目标是用一种计算机管理的连续方法来测量运动中的呼吸困难，以取代离散的秤。在第三阶段上市的产品将是一个计算机软件包，将由世界各地的医生、诊所和医院购买。