A Flowmeter With Telemetry for Chronic Animal Studies

用于慢性动物研究的遥测流量计

• 批准号: 6583625
• 负责人: G J MILANOWSKI
• 金额: $ 39.72万
• 依托单位: TRANSONIC SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-11-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6583625
• 关键词: biomedical device power system; biomedical equipment development; blood flow measurement; implant; longitudinal animal study; medical implant science; microprocessor /microchip; miniature biomedical equipment; monitoring device; portable biomedical equipment; sheep; telemetry

DESCRIPTION (provided by applicant):Continuous blood flow measurement with implanted sensors reduces the number of animals studied because implanted sensors lower measurement variability and improve accuracy. However, current flowmeter technology requires that animals be tethered to recording hardware. This puts the animal and the surgical instrumentation investment at risk, while the stressful experimental setting may alter flow. Transonic Systems will resolve this problem by developing a miniaturized; battery powered wireless flowmeter compatible with existing, and chronically implantable flow probes. Small enough to be implanted in larger animals or attached as a "backpack" to the rat, it will transmit real-time flow from free-roaming animals. Its accuracy will match current benchtop flowmeters; its low power consumption will enable chronic studies. During Phase-I bench/animal tests demonstrated the feasibility and performance of new flowmeter circuitry that can be converted into a custom low-power flowmeter chipset. The Phase-II research will implement/validate a flowmeter LSI chipset that can be integrated with off-the-shelf telemetry chips, and can run for 100 hours on a coin-cell battery. During Phase-Ill commercialization we will market the chip-set to research instrumentation manufacturers for integration with existing telemetry systems, and also to the growing number of medical device manufacturers needing low-power flowmetry for implanted LVAD/mechanical heart devices.

描述（由申请人提供）：植入式传感器的连续血流测量减少了研究动物的数量，因为植入式传感器降低了测量变异性并提高了准确性。然而，目前的流量计技术需要将动物拴在记录硬件上。这使动物和手术器械投资处于风险之中，而压力实验设置可能会改变血流。跨音速系统公司将通过开发一种小型化的电池供电无线流量计来解决这个问题，该流量计与现有的长期植入式流量探头兼容。它足够小，可以植入较大的动物体内，或者作为一个“背包”附着在老鼠身上，它将从自由漫游的动物那里传输实时流。其精度将与当前的台式流量计相匹配;其低功耗将使长期研究成为可能。在第一阶段的台架/动物试验期间，证明了新流量计电路的可行性和性能，该电路可转换为定制的低功耗流量计芯片组。第二阶段研究将实施/验证一个流量计LSI芯片组，该芯片组可以与现成的遥测芯片集成，并可以在纽扣电池上运行100小时。在第三阶段商业化期间，我们将向研究仪器制造商销售芯片组，以便与现有遥测系统集成，并向越来越多的医疗设备制造商销售植入式LVAD/机械心脏设备所需的低功率流量计。