A FLOWMETER WITH TELEMETRY FOR CHRONIC ANIMAL STUDIES

用于慢性动物研究的遥测流量计

• 批准号: 6141673
• 负责人: G J MILANOWSKI
• 金额: $ 9.61万
• 依托单位: TRANSONIC SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2002-04-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6141673
• 关键词: biomedical device power system; biomedical equipment development; blood flow measurement; implant; longitudinal animal study; medical implant science; microprocessor /microchip; miniature biomedical equipment; portable biomedical equipment; sheep; telemetry

Blood flow measurement is vital to many research studies, and is best done with implanted sensors. This reduces the number of animals studied because implanted sensors lower measurement variability and improve accuracy. However, current flowmeter technology requires that the animals be hard-wired to the recording instrument. This puts the animal and the investment in surgical instrumentation at risk, and may alter flow due to the stressful experimental setting. Transonic Systems will resolve this problem by developing a miniaturized, battery powered wireless flowmeter. This device will drive surgically implanted flow probes and transmit realtime flow from free- roaming animals. It will be small enough to be implanted in larger animals or attached as a "backpack" to the rat. It will have the accuracy of current benchtop flowmeters and a battery life matched to typical chronic studies. The Phase-I research will demonstrate concept feasibility by integrating a commercial telemetry system with a miniaturized low-power flowmeter module implemented as a hybrid microcircuit, and will conduct bench and field studies to determine measurement accuracy. Subsequent Phase- II research will develop a custom integrated circuit chip-set that implements a complete flowmeter. During Phase-III commercialization we will make the chip-set available to all research instrumentation manufacturers. PROPOSED COMMERCIAL APPLICATIONS: A miniaturized, affordable flow module with telemetry has exciting commercial potential, since researchers could immediately apply it to chronic studies involving rats, primates, and pigs. Established biomedical equipment suppliers could integrate the flowmeter chip set with their other physiological sensors and their own telemetry systems. The same hardware could be adapted for medical uses such as flow measurement in Ventricular Assist Devices, and monitoring flow changes after cardiac bypass surgery.

血流测量对于许多研究至关重要，最好使用植入式传感器进行。这减少了研究的动物数量，因为植入的传感器降低了测量的可变性并提高了准确性。然而，当前的流量计技术要求动物与记录仪器硬连线。这使动物和手术器械的投资处于风险之中，并且可能由于压力实验设置而改变流动。跨音速系统将解决这个问题，开发一个小型化，电池供电的无线流量计。该装置将驱动外科植入的流量探头，并传输自由漫游动物的实时流量。它将足够小，可以植入较大的动物体内，或者作为“背包”附着在老鼠身上。它将具有当前台式流量计的准确性和与典型慢性研究相匹配的电池寿命。第一阶段研究将通过将商业遥测系统与作为混合微电路实施的小型化低功率流量计模块集成来证明概念可行性，并将进行实验室和现场研究以确定测量精度。随后的第二阶段研究将开发一个定制的集成电路芯片组，实现一个完整的流量计。在第三阶段商业化期间，我们将向所有研究仪器制造商提供芯片组。拟议的商业应用：一个小型化的、负担得起的带有遥测功能的流量模块具有令人兴奋的商业潜力，因为研究人员可以立即将其应用于涉及大鼠、灵长类动物和猪的慢性研究。成熟的生物医学设备供应商可以将流量计芯片组与其他生理传感器和自己的遥测系统集成在一起。相同的硬件可以适用于医疗用途，例如心室辅助装置中的流量测量，以及心脏搭桥手术后的流量变化监测。