The Role of Nore1 Class Effectors in Ras Mediated Transf

Ras癌基因介导多种促进肿瘤发生转化的生物学效应。然而，Ras的活化形式也具有惊人数量的抗转化方面。它们可以通过凋亡诱导衰老、细胞周期阻滞甚至死亡。这些抗新弹性效应背后的机制仍然知之甚少。我们已经确定了一个家庭的新的Ras效应器，似乎调解的Ras的抗肿瘤活性。尤其是凋亡。我们现在已经确定，这个家族中至少有三个成员表现出Ras效应物的所有经典霍尔标记，但也表现出肿瘤抑制物的特性。也就是说，介导细胞生长和转化的抑制，并且在肿瘤发展过程中经常下调。因此，我们已经确定并部分表征了一类新的Ras激活的肿瘤抑制因子。

The Ras oncogene mediates a variety of biological effects which promote tumorigenic transformation. However, activated forms of Ras also have a surprising number anti-transformation aspects. They can induce senesence, cell cycle arrest and even death by apoptosis. The mechanisms behind these anti-neolastic effects remain poorly understood. We have identified a family of novel Ras effectors which appear to mediate some of the anti-neoplastic activities of Ras. especialy apoptosis. We have now determined that at least three members of this family exhibit all the classic hall marks of Ras effectors yet also demionstrate the properties of tumor suppressors. Namely, the mediate inhibition of cell growth and transformation and are frequently down-regulated during tumor development. Thus, we have identified and partially characvterized a novel class of Ras activated tumor suppressor.