Hypothalamic Effects of St John's Wort Phytochemicals

圣约翰草植物化学物质的下丘脑作用

• 批准号: 6666251
• 负责人: MA-LI WONG
• 金额: $ 15.92万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6666251
• 关键词: alternative medicine; antidepressants; drug discovery /isolation; drug screening /evaluation; genetic transcription; hypothalamus; laboratory rat; medicinal plants; plant extracts; psychopharmacology

DESCRIPTION: This investigation will determine if the long term (8 weeks) administration of Hypericum perforatum to rats regulates ARTs similarly to, or differently from, long-term administration of prototypic antidepressant drugs. Additional data to be gained include the nature of any changes in ARTs during the course of Hypericum perforatum and whether this long-term administration regulates expression of genes thought to be activated during major depressive disorder (MDD). This study will offer information to be utilized to provide guidance in terms of dose and mechanism of action for subsequent phase I/II studies.

描述：这项调查将确定是否长期（8 周） 给大鼠施用贯叶金丝桃可调节 ART，类似于，或 与长期服用原型抗抑郁药物不同。 要获得的其他数据包括 ART 期间任何变化的性质 贯叶金丝桃的病程及是否长期服用 调节被认为在重度抑郁期间被激活的基因的表达 障碍（MDD）。这项研究将提供可用于提供的信息 后续 I/II 期剂量和作用机制方面的指导 研究。