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Hypothalamic Effects of St John's Wort Phytochemicals

Hypothalamic Effects of St John's Wort Phytochemicals
圣约翰草植物化学物质的下丘脑作用
批准号:
6666251
负责人:
MA-LI WONG
金额:
$15.92万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-08-01 至 2003-07-31

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英文摘要
DESCRIPTION: This investigation will determine if the long term (8 weeks) administration of Hypericum perforatum to rats regulates ARTs similarly to, or differently from, long-term administration of prototypic antidepressant drugs. Additional data to be gained include the nature of any changes in ARTs during the course of Hypericum perforatum and whether this long-term administration regulates expression of genes thought to be activated during major depressive disorder (MDD). This study will offer information to be utilized to provide guidance in terms of dose and mechanism of action for subsequent phase I/II studies.
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