Functional anatomy of cortical auditory disorders

描述（由申请人提供）：本研究旨在进一步了解听觉皮层对语音、音乐和声音感知相关的基本心理声学功能（如频率识别）的贡献。该结果可能为感觉失语症、先天性听觉障碍及相关综合征的诊断和治疗提供新的途径。对脑卒中患者和颞叶切除术患者的听觉皮层及连接结构病变进行前瞻性、定量的感知缺陷和病理解剖相关性分析。提出的实验建立在先前在心理声学、神经学和神经解剖学方面的工作基础上。对照人群的研究也将提供一个机会来估计正常成年人心理声学功能的差异。实验系列包括测量临界带宽，频率判别，强度判别，虚拟音高感知，非谐波检测，听觉启动，粗糙度检测和频率模式判别。脑卒中和颞叶切除的位置和体积将使用多平面、多序列MRI进行分析。此外，术前PET将用于分析具有同侧内侧颞叶灶的复杂部分性癫痫患者的颞上叶葡萄糖低代谢。

DESCRIPTION (provided by applicant): The proposed research seeks to advance knowledge about the contribution of auditory cortex to basic psychoacoustic functions (e.g. frequency discrimination) in relation to speech, music, and voice perception. The results could lead to new approaches in the diagnosis and treatment of sensory aphasia, congenital auditory disorders, and related syndromes. Prospective, quantitative analyses of perceptual deficits and pathoanatomical correlates will be undertaken in stroke patients and temporal lobectomy patients with lesions of auditory cortex and connected structures. The proposed experiments build on previous work in psychoacoustics, neurology, and neuroanatomy. Studies of control populations also will provide an opportunity to estimate the variance in psychoacoustic functions among normal adults. The experimental series includes measurements of critical bandwidth, frequency discrimination, intensity discrimination, virtual pitch perception, inharmonicity detection, auditory priming, roughness detection, and frequency pattern discrimination. The location and volume of strokes and temporal lobe excisions will be analyzed using multiplanar, multisequence MRI. In addition, pre-operative PET will be used to analyze glucose hypometabolism in the superior temporal lobe of complex partial seizure patients with ipsilateral medial temporal lobe foci.