Core--Tissue Culture Core

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An advantage of conducting research within a coordinated Program Project is the ability to create core facilities to (i) most efficiently and economically take advantage of shared and common resource and administrative needs, (ii) provide mechanisms for disseminating results and facilitating discussions of ongoing research within the group, and (iii) coordinate interactions with investigators outside the program to obtain critical evaluation, technical advice and intellectual input to keep the work on track and at the cutting edge of technologies in the field. To this end an Administrative and Tissue Culture/Animal Core (Core A) will be created and directed by Dr. Christine Gall. Core A will address 6 specific Aims. Aim 1 is to establish Tissue Culture/Animal Core facilities to assure the various projects are using comparable tissue, and to make most the economical use of animal resources and technical support; this will entail training and oversight of technical personnel for hippocampal slice culture preparation, support for ongoing culture needs of the group and maintenance of animal colonies. Aim 2 is to provide ampakine drugs and shared chemical reagents (ampakines, BDNF peptides and antagonists) to the different projects; this includes contracting the synthesis of ampakines from outside sources. Aim 3 is to disseminate research findings and coordinate collaborative research activities within the Program Project: this will be accomplished through monthly meetings of all program investigators in addition to more frequent meetings of smaller collaborative groups. Aim 4 is to coordinate interactions with outside investigators to provide review and oversight, technical advice, and outside intellectual input to program investigators. To this end formal internal and external advisory boards have been created; each is composed of outstanding investigators with specific expertise relating to objectives of the Program Subprojects. In addition, the Program will support a series of Research Seminars to provide fresh ideas and a venue for interactions with investigators doing related work. Aim 5 is to provide general Administrative support and assistance for computer systems within the group. Finally, Aim 6 is to assure ongoing compliance with institutional regulations pertaining to material use, animal research, and laboratory safety.