ICAL: Impact of Cannabinoids Across Lifespan: Pilot Project Core

ICAL：大麻素对整个生命周期的影响：试点项目核心

• 批准号: 10188477
• 负责人: Christine M Gall
• 金额: $ 7.37万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188477
• 关键词: Adolescence; Adolescent; Anatomy; Architecture; Area; Behavior; Behavioral; Blood specimen; Brain; Cannabinoids; Cannabis; Child; Cognition; Collaborations; Communities; Consultations; Department chair; Doctor of Philosophy; Electrophysiology (science); Enrollment; Ensure; Epigenetic Process; Exposure to; Faculty; Fostering; Funding; Genetic Processes; Individual; Institutes; Leadership; Longevity; Mentors; Mentorship; Mission; Molecular; Molecular Structure; Mus; National Institute of Drug Abuse; Neurobiology; Neurosciences; Pilot Projects; Rattus; Research; Research Personnel; Resources; Sum; Supervision; System; Talents; Testing; Tissue Banks; Training; United States National Institutes of Health; Work; addiction; career development; cognitive development; comparative; design; endogenous cannabinoid system; innovation; member; motivated behavior; professor; programs; recruit; senior faculty; synaptic function; synergism

PROJECT SUMMARY: PILOT CORE The proposed NIDA Center of Excellence, entitled Impact of Cannabinoids Across the Lifespan (ICAL), will test the hypothesis that non-physiological activation of the endocannabinoid system in adolescence – caused by exposure to THC or one of its synthetic mimics – initiates a reprogramming of the genetic and epigenetic processes that govern this system’s molecular structure, neuroanatomical architecture, and synaptic functions, ultimately producing persistent abnormalities in cognition and motivated behavior. To test this hypothesis, ICAL will deploy a vertically integrated strategy combining molecular, neuroanatomical, electrophysiological, and behavioral approaches. ICAL’s scientific and programmatic objectives will yield many opportunities for neuroscience and addiction researchers to explore exciting new avenues of research. ICAL’s Pilot Core is designed to fulfill two major objectives of the Center: (1) to foster innovative research that aligns with the Center’s scientific mission and maximizes use of its research resources; and (2) to provide high-quality career development activities and mentorship for junior investigators and/or investigators new to cannabinoid research. The Pilot Core will achieve these objectives via its annual competition for pilot funding. The Core Director, Christine Gall, PhD, is Professor and Chair of the Department of Anatomy & Neurobiology and Professor of Neurobiology & Behavior at UCI. Dr. Gall will supervise the recruitment of projects and oversee their progress in consultation with the Center director and co-director, the internal Steering Committee (SC) and External Advisory Group (EAG). The Center’s Administrative Core will provide clerical support for this Core. Junior investigators and/or investigators new to the field who receive ICAL pilot funding will be paired with senior faculty members who will provide mentorship during the pilot project funding period and after research is completed. In addition, pilot grantees will have access to the leadership and expertise of the SC and the EAG. The Pilot Core will serve as a conduit for the exploration of new ideas as well as an important venue for mentoring junior investigators and those new to the field. The Core’s leadership will work to ensure that the potential for each individual project and project investigator is fully realized. !

项目概要：试点核心 拟议的NIDA卓越中心，题为大麻素对整个生命周期的影响（ICAL）， 将检验青春期内源性大麻素系统的非生理激活 - 由暴露于THC或其合成模拟物之一引起-启动基因的重新编程 以及控制这个系统的分子结构，神经解剖结构， 和突触功能，最终导致认知和动机的持续异常， 行为为了验证这一假设，ICAL将部署一项垂直整合战略，将分子、 神经解剖学、电生理学和行为学方法。ICAL的科学性和纲领性 目标将为神经科学和成瘾研究人员提供许多机会， 研究的新途径。ICAL的试点核心旨在实现中心的两个主要目标：（1） 促进创新研究，符合中心的科学使命，并最大限度地利用其 研究资源;及（2）提供高质素的职业发展活动及导师服务， 初级研究人员和/或大麻素研究新手。试点核心将实现这些目标 通过每年的试点资金竞争实现目标。核心主任克莉丝汀加尔博士是 解剖学和神经生物学系教授和系主任，神经生物学和神经生物学教授 在UCI的行为。Gall博士将监督项目的招聘，并监督其进展， 与中心主任和联合主任，内部指导委员会（SC）和外部 咨询小组（EAG）。该中心的行政核心将为该核心提供文书支持。 接受ICAL试点资助的初级研究者和/或新进入该领域的研究者将配对 与资深教师谁将提供指导在试点项目资助期间， 研究完成后。此外，试点受赠方将有机会接触到 在SC和EAG。试点核心也将作为探索新想法的渠道 作为指导初级调查员和外地新人的一个重要场所。该芯体的 领导层将努力确保每个项目和项目调查员的潜力 完全实现。 !