ICAL: Impact of Cannabinoids Across Lifespan: Pilot Project Core

ICAL：大麻素对整个生命周期的影响：试点项目核心

• 批准号: 10188477
• 负责人: Christine M Gall
• 金额: $ 7.37万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188477
• 关键词: Adolescence; Adolescent; Anatomy; Architecture; Area; Behavior; Behavioral; Blood specimen; Brain; Cannabinoids; Cannabis; Child; Cognition; Collaborations; Communities; Consultations; Department chair; Doctor of Philosophy; Electrophysiology (science); Enrollment; Ensure; Epigenetic Process; Exposure to; Faculty; Fostering; Funding; Genetic Processes; Individual; Institutes; Leadership; Longevity; Mentors; Mentorship; Mission; Molecular; Molecular Structure; Mus; National Institute of Drug Abuse; Neurobiology; Neurosciences; Pilot Projects; Rattus; Research; Research Personnel; Resources; Sum; Supervision; System; Talents; Testing; Tissue Banks; Training; United States National Institutes of Health; Work; addiction; career development; cognitive development; comparative; design; endogenous cannabinoid system; innovation; member; motivated behavior; professor; programs; recruit; senior faculty; synaptic function; synergism

PROJECT SUMMARY: PILOT CORE The proposed NIDA Center of Excellence, entitled Impact of Cannabinoids Across the Lifespan (ICAL), will test the hypothesis that non-physiological activation of the endocannabinoid system in adolescence – caused by exposure to THC or one of its synthetic mimics – initiates a reprogramming of the genetic and epigenetic processes that govern this system’s molecular structure, neuroanatomical architecture, and synaptic functions, ultimately producing persistent abnormalities in cognition and motivated behavior. To test this hypothesis, ICAL will deploy a vertically integrated strategy combining molecular, neuroanatomical, electrophysiological, and behavioral approaches. ICAL’s scientific and programmatic objectives will yield many opportunities for neuroscience and addiction researchers to explore exciting new avenues of research. ICAL’s Pilot Core is designed to fulfill two major objectives of the Center: (1) to foster innovative research that aligns with the Center’s scientific mission and maximizes use of its research resources; and (2) to provide high-quality career development activities and mentorship for junior investigators and/or investigators new to cannabinoid research. The Pilot Core will achieve these objectives via its annual competition for pilot funding. The Core Director, Christine Gall, PhD, is Professor and Chair of the Department of Anatomy & Neurobiology and Professor of Neurobiology & Behavior at UCI. Dr. Gall will supervise the recruitment of projects and oversee their progress in consultation with the Center director and co-director, the internal Steering Committee (SC) and External Advisory Group (EAG). The Center’s Administrative Core will provide clerical support for this Core. Junior investigators and/or investigators new to the field who receive ICAL pilot funding will be paired with senior faculty members who will provide mentorship during the pilot project funding period and after research is completed. In addition, pilot grantees will have access to the leadership and expertise of the SC and the EAG. The Pilot Core will serve as a conduit for the exploration of new ideas as well as an important venue for mentoring junior investigators and those new to the field. The Core’s leadership will work to ensure that the potential for each individual project and project investigator is fully realized. !

项目总结：试点核心 拟议的NIDA英才中心，题为大麻类物质对寿命的影响(ICAL)， 将检验青春期内源性大麻素系统非生理性激活的假说 -由接触THC或其合成模拟物引起-启动基因的重新编程 以及控制这个系统的分子结构、神经解剖结构的表观遗传过程， 和突触功能，最终导致认知和动机的持续性异常 行为。为了验证这一假设，ICAL将部署一种垂直整合的策略，将分子、 神经解剖学、电生理学和行为学方法。ICIC的科学性和纲领性 目标将为神经科学和成瘾研究人员提供许多探索令人兴奋的机会 研究的新途径。ICAL的Pilot Core旨在实现该中心的两个主要目标：(1) 促进符合中心科学使命的创新研究，并最大限度地利用其 研究资源；及(2)为以下人士提供优质的职业发展活动和辅导 初级调查员和/或大麻素研究新手。Pilot Core将实现这些 通过一年一度的试点资金竞赛实现目标。核心总监克里斯汀·加尔博士是 解剖与神经生物学系教授、主任，神经生物学与神经生物学系教授 加州大学洛杉矶分校的行为。Gall博士将监督项目的招募并监督其进展情况 与中心主任和联席主任、内部指导委员会(SC)和外部 顾问组(EAG)。该中心的行政核心将为该核心提供文书支持。 初级调查员和/或接受临床试验资助的新领域调查员将配对 与资深教员合作，他们将在试点项目资助期内提供指导，并 在研究完成之后。此外，试点受赠人将有机会获得领导力和专业知识 常委和EAG。试点核心也将成为探索新想法的渠道 作为指导初级调查人员和该领域新手的重要场所。核心的 领导层将努力确保每个项目和项目调查员的潜力是 完全意识到了。 好了！