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ICAL: Impact of Cannabinoids Across Lifespan: Pilot Project Core

ICAL：大麻素对整个生命周期的影响：试点项目核心

基本信息

批准号：
10188477
负责人：
Christine M Gall
金额：
$ 7.37万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10188477
关键词：
Adolescence Adolescent Anatomy Architecture Area Behavior Behavioral Blood specimen Brain Cannabinoids Cannabis Child Cognition Collaborations Communities Consultations Department chair Doctor of Philosophy Electrophysiology (science)Enrollment Ensure Epigenetic Process Exposure to Faculty Fostering Funding Genetic Processes Individual Institutes Leadership Longevity Mentors Mentorship Mission Molecular Molecular Structure Mus National Institute of Drug Abuse Neurobiology Neurosciences Pilot Projects Rattus Research Research Personnel Resources Sum Supervision System Talents Testing Tissue Banks Training United States National Institutes of Health Work addiction career development cognitive development comparative design endogenous cannabinoid system innovation member motivated behavior professor programs recruit senior faculty synaptic function synergism

项目摘要

PROJECT SUMMARY: PILOT CORE The proposed NIDA Center of Excellence, entitled Impact of Cannabinoids Across the Lifespan (ICAL), will test the hypothesis that non-physiological activation of the endocannabinoid system in adolescence – caused by exposure to THC or one of its synthetic mimics – initiates a reprogramming of the genetic and epigenetic processes that govern this system’s molecular structure, neuroanatomical architecture, and synaptic functions, ultimately producing persistent abnormalities in cognition and motivated behavior. To test this hypothesis, ICAL will deploy a vertically integrated strategy combining molecular, neuroanatomical, electrophysiological, and behavioral approaches. ICAL’s scientific and programmatic objectives will yield many opportunities for neuroscience and addiction researchers to explore exciting new avenues of research. ICAL’s Pilot Core is designed to fulfill two major objectives of the Center: (1) to foster innovative research that aligns with the Center’s scientific mission and maximizes use of its research resources; and (2) to provide high-quality career development activities and mentorship for junior investigators and/or investigators new to cannabinoid research. The Pilot Core will achieve these objectives via its annual competition for pilot funding. The Core Director, Christine Gall, PhD, is Professor and Chair of the Department of Anatomy & Neurobiology and Professor of Neurobiology & Behavior at UCI. Dr. Gall will supervise the recruitment of projects and oversee their progress in consultation with the Center director and co-director, the internal Steering Committee (SC) and External Advisory Group (EAG). The Center’s Administrative Core will provide clerical support for this Core. Junior investigators and/or investigators new to the field who receive ICAL pilot funding will be paired with senior faculty members who will provide mentorship during the pilot project funding period and after research is completed. In addition, pilot grantees will have access to the leadership and expertise of the SC and the EAG. The Pilot Core will serve as a conduit for the exploration of new ideas as well as an important venue for mentoring junior investigators and those new to the field. The Core’s leadership will work to ensure that the potential for each individual project and project investigator is fully realized. !

项目总结：试点堆芯